醫學研究科

[醫研科行政業務] [動物研究實驗室] 

[心臟血管研究室] [神經結構與功能研究室] [流行病學研究室]

[細胞藥理學研究室] [基因工程研究室] [感染疾病與免疫學研究室] [癌症基因體研究室]

Laboratory of Infectious Disease and Immunology

張聰賢 博士 副研究員                                           

Tsung-Hsien Chang Ph. D.

研究專長

Molecular Virology

Innate Immunology

Signal Transduction

聯絡資料

地址：81362高雄市左營區大中一路386號, 教研部3F

電話：(07) 342-2121 ext. 1562

傳真：(07) 346-8506

最高學歷      

博士  國防醫學院 生命科學研究所 (2005)

學術經歷

副研究員  高雄榮民總醫院 教學研究部 (現職2010~)

訪問研究學者  美國國家衛生研究院 國立兒童健康與人類發展研究所 (NICHD/NIH, 2006~2010)

博士後研究員  中央研究院 生物醫學科學研究所 (2005~2006)

獲獎與榮譽

美國國家衛生研究院 傑出研究獎 (FARE 2010)

國防醫學院 優秀博士論文獎 (2004)

財團法人陳宗仁先生免疫學研究發展基金會 成績優異獎 (1998)

證照

醫事人員 醫事檢驗師執照

專門技術人員 高等考試-醫事檢驗師

目前研究方向

1. 登革病毒調控第一型干擾素產生之分子機制

2. 蛋白質轉譯後修飾作用與先天性免疫反應的關係

3. 轉錄因子調控樹突細胞的發育與活性 

My major research interest is in the fields of virus infection and host innate immune response. We have focused on the role of post-translation modification, such as SUMOylation and Ubiquitination, regulating Interferon and inflammatory cytokines expression by dendritic cells (DCs) and macrophages.

期刊論文

Articles:

1.      Yu, C.-Y., Chiang R.-L., Chang T.-H., Liao, C.-L., Lin Y.-L. The Interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases Journal of Virology 2010, 84:2424-31

2.      Ozato K., Yoshimi R. Chang T.-H., Atsumi T., Wang H, and Morse III HC. Comment on “Gene Disruption study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-kB-Dependent Cytokine Expression in Fibroblasts” Journal of Immunology 2009, 183:7619.

3.      Chang, T.-H., Kubota, T., Matsuoka, M., Jones, S., Bray, M., and Ozato, K. Ebola virus VP35 blocks type I interferon transcription in dendritic cells by interacting with the cellular SUMOylation machinery. pLoS Pathogens 2009, Jun;5(6):e1000493.

4.      Yoshimi R. Chang T.-H., Atsumi T., Wang H, Morse III HC., and Ozato K. TRIM21, the autoantigen Ro52/SS-A, is involved in NF-kB-dependent cytokine and TRIM family gene regulation. Journal of Immunology 2009, 182(12): 7527-38.

5.      Kubota, T., Matsuoka, M., Chang, T.-H., Bray M., Jones, S, Tashiro, M., Kato, A., and Ozato K. Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. Journal of Virology 2009, 83:6952-6.

6.      Chan, Y.-L., Chang, T.-H., Liao C.-L., Lin Y.-L. The Cellular Antiviral protein Viperin is attenuated by proteasome-mediated protein degradation in Japanese Encephalitis Virus-Infected Cells. Journal of Virology 2008, 82(21): 10455-64.

7.      Ozato, K., Shin, D.-M., Chang, T.-H., and Morse III, HC. TRIM family proteins and their emerging roles in innate immunity. Nature Immunology Review 2008, 8(11): 849-60.

8.      Kubota, T., Matsuoka, M., Chang, T.-H., Tailor, P., Sasaki, T., Tashiro, M., Kato A., and Ozato, K. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. Journal of Biological Chemistry 2008, 81(17): 8967-76.

9.      Chang, T.-H., Liao, C.-L. Lin, Y.-L. Flavivirus induced interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kB activation. Microbes and Infection 2006, 8(1): 157-71.

10.  Hung, J.-T., Liao, J.-H., Lin, Y.-C., Chang, H.-Y., Wu, S.-F., Chang, T.-H., Kung J.-T., Hsieh, S.-L., McDevitt, H., and Sytwu, H.-K., Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. Journal of Autoimmunity 2005, 25(3): 181-92.

研討會論文

Conference Abstracts

1.      Ozato K., Chang T.-H., Kubota T., Matsuoka M., Bray M., and Jones S. Inhibition of type I interferon transcription by IRF3/7 SUMOylation the process hijacked by the Ebola virus VP35. Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research, Cellular and Cytokine Interactions in Health and Disease. Cytokine 2009 (48) 15.

2.      Ng S., Chang T.-H., Tailor P., Ozato K. and Kino T. Viral infection alters mRNA expression of nuclear hormone receptors and their coregulators in mouse dendritic cells. The 96th annul meeting of American Association of Immunologists, Seattle, Washington. USA. May 8-12 2009.

3.      Ozato K., Tailor P., Ramakrishna L., Chang T.-H., Kubota T., Mayumi Matsuoka M. and Morse3rd C.H. The mechanism of interferon gene transcription in dendritic cells.  7thJoint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research. Cytokine 2008, 43(3) 277.

4.      Kubota T, Matsuoka M., Chang T.-H., Tashiro M., Kato A., and Ozato K. Ebola virus VP35 interacts with host microtubule associated transporter dynein LC8 IUMS 2008- Joint Meetings of the Three Divisions of the International Union of Microbiological Societies, Istanbul, Turkey. August 10-15, 2008.

5.      Yu C.-Y., Chang T.-H., Chiang R.-L., and Lin, Y.-L. Crosstalk of interferon pathway and unfolded protein response in flavivirus infection. Journal of Interferon & Cytokine Research. August 1, 2007, 27(8): 713-738.

6.      Chang, T.-H., and Lin Y.-L. Attenuation interferon pathway by dengue viral protease through a RIG-I-dependent mechanism. 6th International Cytokine Conference, Vienna, Austria, August 27-31, 2006 (European Cytokine Network, Supplement Aug. 2006, 17: 128, 12-19/p).

7.      Chen J.-B., Chang, T.-H., Lin Y.-L., and Lin K.-I., The physiological role of Blimp-1 in viral infection. Joint Annual Meeting-The Rheumatology Association, & The Chinese Society of Immunology, Taiwan, ROC. December 16-17, 2006.

8.      Chan, Y.-L., Chang, T.-H., Liao C.-L. and Lin Y.-L. The Antiviral and Gene Induction Mechanisms of a Host Gene Viperin against Positive-Sensed RNA viruses. IUMS 2005- Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies, San Francisco, California, USA Moscone Convention Center, July 23-28, 2005.

9.      Lin, R.-J., Chang, T.-H., Liao, C.-L., and Lin, Y.-L. Multifaceted interplays between type-I interferon and flaviviruses. First Asia Regional Dengue Research Network Meeting. Bangkok, Thailand, October 18-20, 2004.

10.  Chang, T.-H., and Lin, Y.-L. Distinct interferon-beta activation mechanisms applied by members of flavivirus. American Society for Virology, 23th Annual Meeting, McGill University, Montreal, Quebec, Canada. July 10-14, 2004.

11.  Chang, T.-H., and Lin, Y.-L. Flavivirus induce interferon-beta expression through an IRF-3 and NF-kappa B dependent pathway. American Society for Virology, 22th Annual Meeting, University of California, Davis, California U.S.A. July 12-16, 2003.