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醫學研究科
[醫研科行政業務] [心臟血管研究室] [神經結構與功能研究室] [流行病學研究室]
[細胞藥理學研究室] [基因工程研究室] [動物研究實驗室]
Laboratory of Cellular Pharmacology
主持人: 簡崇仁 教授（Chung-Ren Jan, Ph.D.）
Email:crjan@isca.vghks.gov.tw
助理研究員: 何金滿（Chin-Man Ho, M. S.）
研究生：蔡政諭 ( Jeng-Yu Tsai, 中山大學生科所博士班)
方譯謙 ( Yi-Chien Fang, 中山大學生科所博士班)
潘志泉 ( Chih-Chuan Pan, 中山大學生科所博士班)
郭純綺 (Chun-Chi Kuo, 中山大學生科所博士班)
研究助理:郭晏岑 ( Yen-Tsen Kuo ) Tel: (07)3422121 x 1508 & 1509
 :crjan@isca.vghks.gov.tw
How to write the scientific manuscript 請直接點選下載
 
學歷
博士後 美國北卡杜克大學 美國 神經生物暨藥理 1992/10-1994/12 博士 紐約州奧伯尼醫學院
美國 藥理 1987/8-1992/10
碩士 台灣大學 中華民國 農化 1984/8-1987/12
學士 台灣大學 中華民國 農化 1980/8-1983/6
經歷
2002/1- 高雄榮總教研部研究員 2001/7- 教育部頒定教授(教字第011594號)
2000/3- 輔英技術學院兼任教授 1997/8- 中山大學生物系兼任教授 1997/2- 教育部頒定副教授 (副字第025022號)
1996/8- 國防醫學院藥理系兼任副教授
1995/1- 高雄榮總教研部副研究員
Research Interest:
利用螢光染料測定細胞內離子濃度之變化，及其與細胞功能之間的關係、所測之離子包括：鈣、氫和鈉，所用細胞為細胞株，實驗方法有二：１〕利用單一細胞，以數字化攝影（digital video imaging）測定。２〕利用懸浮細胞群（cell suspension）以螢光光譜儀（fluorescence spectrophotometer）測定。
利用西方點墨法(Western blot)研究細胞內有關訊息傳導路徑蛋白質（如MAPKs、STAT、PKC…）表現。利用流式細胞儀觀察藥物是否會誘導細胞產生細胞凋亡（apoptosis）。利用RT-PCR來偵測一些與鈣離子、鈣離子通道、發炎或細胞凋亡有關的基因表現。
Honour
1. 89年度行政院全國傑出研究獎
2. 89年度SCI總公司( ISI)台灣經典引文獎(2001.9.10)
3. Reviewer of Journal of Neurochemistry (2001)
4. Reviewer of Biochemical Pharmacology (2001)
5. Reviewer of Life Sciences (2001)
6. Reviewer of Journal of British Pharmacology (2003. Aug.)
7. Reviewer of European Journal of Pain (2005, July)
8. 89年度榮清陽計畫年度報告壁報組第一名
9. 89年度中華藥理學會優秀論文獎
10. 88年度嚴慶齡基礎科學研究獎
11. 86, 88, 89, 92年度國科會甲種獎勵
Publication:.
1.
Shieh
P, Lee CH, Yi NL, Jan CR*. Carvedilol-induced elevation in
cytosolic free Ca2+ level and apoptosis in SIRC corneal
epithelial cells. Hum Exp Toxicol.
2009 Dec 22. [Epub ahead of print]
2.
Huang
CJ, Kuo DH, Chang KH, Shieh P, Chen FA, Fang YC, Kuo CC, Jan CR*.
Effect of the Antidepressant Sertraline on Ca(2+) Fluxes
in Madin-Darby Canine Renal Tubular Cells. J
Recept Signal Transduct Res. 2009
Dec;29(6):342-8.
3.
Tsai
NW*, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD,
Chuang YC, Lee LH, Lu CH. Serial Change in Platelet Activation
Markers With Aspirin and Clopidogrel After Acute Ischemic Stroke. Clin
Neuropharmacol. 2009 Oct 22. [Epub ahead of
print]
4.
Huang
CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST,
Ho CM, Lin KL, Tsai JY, Jan CR*. Effects of Antrodia
camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs
phosphorylation of OC2 human oral cancer cells. Chin
J Physiol. 2009 Jun 30;52(3):128-35.
5.
Fang
YC, Kuo DH, Shieh P, Chen FA, Kuo CC, Jan CR*. Effect of
m-3M3FBS on Ca2+ movement in Madin-Darby canine renal tubular cells.
Hum Exp Toxicol. 2009
Oct;28(10):655-63. Epub 2009 Sep 21.
6.
Kuo L, Huang C, Fang Y, Huang C, Wang
J, Lin K, Chu S, Chang H, Chien J, Su H,Chi C, Chen W, Tsai J, Liao
W, Tseng L, Jan C. Effect of thimerosal on Ca2+ movement and
viability in human oral cancer cells. Hum Exp Toxicol. 2009 May;28(5):301-8. Epub 2009 Aug 6.
7.
Lin KL, Huang CC, Cheng JS, Tsai JY, Lu
YC, Chang HT, Jan CR*. Ketoconazole-induced JNK
phosphorylation and subsequent cell death via apoptosis in human
osteosarcoma cells. Toxicology in Vitro 23 (2009) 1268–1276.
8.
Yeh
JH, Huang CC, Yeh MY, Wang JS, Lee JK, Jan CR*.
Cadmium-induced cytosolic Ca2+ elevation and subsequent
apoptosis in renal tubular cells. Basic
Clin Pharmacol Toxicol. 2009 May;104(5):345-51.
9.
Huang
C, Huang C, Cheng J, Liu S, Chen I, Tsai J, Chou C, Tseng P, Jan
C*. Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death
in human oral cancer cells. Hum Exp
Toxicol. 2009 Jan;28(1):41-8.
10.
Huang
JK, Huang CC, Lu T, Chang HT, Lin KL, Tsai JY, Liao WC, Chien JM, Jan
CR*. Effect of MK-886 on Ca Level and Viability in PC3 Human
Prostate Cancer Cells. Basic Clin
Pharmacol Toxicol. 2009 Jun;104(6):441-7.
Epub 2009 Apr 3.
11.
Tsai
NW*, Chang WN, Shaw CF, Jan CR, Huang CR, Chen SD, Chuang YC,
Lee LH, Lu CH. The value of leukocyte adhesion molecules in patients
after ischemic stroke. J Neurol.
2009 Apr 8. [Epub ahead of print]
12.
Tsai
NW*, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD,
Chuang YC, Lee LH, Wang HC, Lee TH, Lu CH. Levels and value of
platelet activation markers in different subtypes of acute
non-cardio-embolic ischemic stroke. Thromb
Res. 2009 Jun;124(2):213-8. Epub 2009 Feb
23.
13.
Jeng-Yu Tsai, Chorng-Chih Huang,
He-Hsiung
Cheng, Ko-Long Lin, Wei-Chuan
Liao, Chung-Ren Jan*. Nonylphenol-Induced Cytosolic
Ca2+ Elevation and Deathin Renal
Tubular Cells. Drug
Develpoment Research 70: 370-377.(2009)
14.
Chao-Chuan Chi, Chorng-Chih Huang, Jau-Min
Chien, Sau-Tung Chu, Wei-Chuan Chen, Hong-Tai Chang, Ko-Long Lin,
Jeng-Yu Tsai, Wei-Chuan Liao, Chiang-Ting Chou, Chung-Ren Jan*.
L-type Ca2+
channel opener BayK 8644-induced Ca2+
influx and Ca2+ release in human oral cancer cells (OC2) DRUG
DEVELOPMENT RESEARCH. 58：508-513(2008)
15.
Chien
JM, Huang CC, Cheng HH, Lin KL, Chen WC, Tseng PL, Chou CT, Tsai JY,
Liao WC, Wang BW, Chang PM, Jan CR*. Econazole-evoked [Ca2+]i
rise and non-Ca2+-triggered cell death in rabbit corneal epithelial
cells (SIRC). J Recept Signal Transduct
Res. 2008;28(6):567-79.
16.
Tsai
NW, Lu CH, Chang WN, Shaw CF, Huang CR, Shang-Der C, Chuang YC, Lee
LH, Jan CR*. DYSREGULATION OF Ca(2+) MOVEMENT IN
PLATELETS FROM PATIENTS WITH ACUTE ISCHAEMIC STROKE. Clin
Exp Pharmacol Physiol. 2009
Apr;36(4):380-5. Epub 2008 Oct 31.
17.
Huang
CC, Cheng HH, Lin KL, Cheng JS, Tsai JY, Liao WC, Fang YC, Jan CR*.
Tamoxifen-induced [Ca2+]i
rise and apoptosis in corneal epithelial cells. Toxicology.
2009 Jan 8;255(1-2):58-64. Epub 2008 Oct 17.
18.
Lu
T, Huang CC, Lu YC, Lin KL, Liu SI, Wang BW, Chang PM, Chen IS, Chen
SS, Tsai JY, Chou CT, Jan CR*. DESIPRAMINE-INDUCED Ca(2+)-INDEPENDENT
APOPTOSIS IN MG63 HUMAN OSTEOSARCOMA CELLS: DEPENDENCE ON P38
MITOGEN-ACTIVATED PROTEIN KINASE-REGULATED ACTIVATION OF CASPASE 3. Clin
Exp Pharmacol Physiol. 2009 Mar;36(3):297-303. Epub 2008 Oct
15.
19.
Chen
WC, Huang CC, Huang CJ, Chien JM, Lin KL, Lu YC, Chen IS, Liu SI,
Hsu SS, Chang HT, Chou CT, Jan CR*. Mechanism of paroxetine-induced
cell death in renal tubular cells. Basic
Clin Pharmacol Toxicol. 2008 Nov;103(5):407-13. Epub 2008 Sep
17.
20.
Liu
SI, Cheng HH, Huang CJ, Chang HC, Chen WC, Chen IS, Hsu SS, Chang
HT, Huang JK, Chen JS, Lu YC, Jan CR*. Melittin-induced [Ca2+]i
increases and subsequent death in canine renal tubular cells. Hum
Exp Toxicol. 2008 May; 27(5):417-24.
21.
Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP,
Tseng PL, Kuo SJ, Jan CR*. Effects of antrodia camphorata on
viability, apoptosis, and [Ca2+]i
in PC3
human prostate cancer cells. Chin J Physiol. 2008 Apr 30;51(2):78-84.
22.
Liao
WC, Huang CC, Cheng HH, Wang JL, Lin KL, Cheng JS, Chai KL, Hsu PT,
Tsai JY, Fang YC, Lu YC, Chang HT, Huang JK, Chou CT, Jan CR*.
Effect of calmidazolium on [Ca2+]i
and viability in human hepatoma cells. Arch
Toxicol. 2009 Jan;83(1):61-8. Epub 2008 Jul 11.
23.
Chang
HC, Huang CC, Huang CJ, Cheng JS, Liu SI, Tsai JY, Chang HT, Huang
JK, Chou CT, Jan CR*. Desipramine-induced apoptosis in human
PC3 prostate cancer cells: Activation of JNK kinase and caspase-3
pathways and a protective role of [Ca2+]i elevation. Toxicology. 2008 Aug 19;250(1):9-14.
Epub 2008 May 27.
24.
Hong-Tai
Chang,
Chorng-Chih Huang, He-Hsiung Cheng, Ti Lu, Jue-Long Wang, Ko-Long
Lin, Pei-Te Hsu, Jeng-Yu Tsai, Wei-Chuan Liao, Yih-Chau Lu,
Jong-Khing Huang, and Chung-Ren Jan*. Effects of MK-886, a
Leukotriene Synthesis Inhibitor, on [Ca2+]i
and Apoptosis in MG63 Human Osteosarcoma Cells. Drug Dev Res 69：49-57(2008)
25.
Roan
CJ, Huang CC, Cheng HH, Chien JM, Chou CT, Lin KL, Liu SI, Lu YC,
Chang HT, Huang JK, Jan CR*. Diethylstilbestrol-Induced
Estrogen Receptor-Dependent [Ca2+]i
Rises and Apoptosis in Chinese Hamster Ovary (CHO) Cells.J Recept
Signal Transduct Res. 2008;28(3):307-22.
26.
Chang
HT, Huang CC, Cheng HH, Wang JL, Lin KL, Hsu PT, Tsai JY, Liao WC,
Lu YC, Huang JK, Jan CR*. Mechanisms of AM404-induced [Ca2+]i
rise and death in human osteosarcoma cells. Toxicol Lett. 2008 Jun
10;179(1):53-8.
Epub 2008 Apr 11.
27.
Chu ST, Huang CC, Huang CJ, Cheng JS,
Chai KL, Cheng HH, Fang YC, Chi CC, Su HH, Chou CT, Jan
CR*.
Tamoxifen-induced [Ca2+]i
rises and Ca2+-independent cell death in human oral cancer cells.J
Recept Signal Transduct Res. 2007;27(5-6):353-67.
28.
Cheng
JS, Huang CC, Chou CT, Jan CR*. Mechanisms of carvedilol-induced
[Ca2+]i
rises and death in human hepatoma cells.Naunyn Schmiedebergs Arch
Pharmacol. 2007 Nov;376(3):185-94.
Epub 2007 Oct 5.
29.
Lu YC, Cheng HH, Huang CJ, Chu ST, Chi CC, Su
HH, Hsu SS, Wang JL, Chen IS, Liu SI, Huang JK, Ho CM, Kuo SJ, Jan
CR*. Effects of Antrodia Camphorata on Viability, Apoptosis, [Ca2+]i,
and MAPKs Phosphorylation in MG63 Human Osteosarcoma Cells. Drug Dev
Res 2007; 68:71-8.pumed
30.
Lin MC, Huang CJ, Cheng HH, Chou CT, Wang JL,
Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan CR*.
Ketoconazole-evoked [Ca2+]i rises and non-Ca2+-triggered
cell death in rabbit corneal
epithelial cell line (SIRC). J Recept Signal Transduct Res 2007;27(4):295-307.
31.
Liu
SI, Huang CC, Huang CJ, Wang BW, Chang PM, Fang YC, Chen WC, Wang JL,
Lu YC, Chu ST, Chou CT, Jan CR*. Thimerosal-induced apoptosis
in human SCM1 gastric cancer cells: activation of p38 MAP kinase and
caspase-3 pathways without involvement of [Ca2+]i elevation.
Toxicol Sci. 2007 Nov;100(1):109-17. Epub 2007 Aug 13.
32.
Chen WC, Cheng HH, Huang CJ, Lu YC, Chen IS,
Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The
carcinogen safrole increases intracellular free Ca2+
levels and causes death in MDCK cells. Chin J Physiol. 2007 Feb
28;50(1):34-40.
33.
Wang JL, Chan RC, Cheng HH, Huang CJ, Lu YC,
Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Ho CM, Jan
CR*. Short waves-induced enhancement of proliferation of human
chondrocytes: involvement of extracellular signal-regulated MAP-Kinase
(ERK). Clin Exp Pharmacol Physiol. 2007 Jul;34(7):581-5.
34.
Huang CJ, Cheng HH, Chou CT, Kuo CC, Lu YC,
Tseng LL, Chiang AJ, Liu SI, Chen IS, Jan CR*. Desipramine-induced
Ca2+ movement and cytotoxicity in PC3 human prostate
cancer cells. Toxicol in Vitro. 2007 Apr;21(3):449-456. Epub 2006
Oct 27.
35.
Hsu SS, Huang CJ, Cheng HH, Chou CT, Lee HY,
Wang JL, Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan
CR*. Anandamide-induced Ca2+ elevation leading to p38
MAPK phosphorylation and subsequent cell death via apoptosis in
human osteosarcoma cells. Toxicology. 2007 Feb 28;231(1):21-9. Epub
2006 Nov 11.
36.
Chou CT, He
S, Jan CR*. Paroxetine-induced apoptosis in
human osteosacroma cells: activation of p38 MAP kinase and caspase-3
pathways without involvement of [Ca2+]i
elevation. Toxicol Appl Pharmacol. 2007 Feb 1;218(3):265-73. Epub
2006 Nov 15.
37.
Chu ST, Cheng HH, Huang CJ, Chang HC, Chi CC,
Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Lu YC, Huang JK, Ho CM, Jan
CR*. Phospholipase A2-independent Ca2+
entry and subsequent apoptosis induced by melittin in human MG63
osteosarcoma cells. Life Sci. 2007 Jan 2;80(4):364-369. Epub 2006
Sep 30.
38.
Pan CC, Cheng HH, Huang CJ, Lu YC, Chen IS,
Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The
antidepressant mirtazapine-induced cytosolic Ca2+
elevation and cytotoxicity in human osteosarcoma cells. Chin J
Physiol. 2006 Dec 31;49(6):290-7.
39.
Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI,
Hsu SS, Chang HT, Wang JK, Lu YC, Jan CR*. Effect of
nortriptyline on intracellular Ca2+ handling and
proliferation in canine renal tubular cells. Chin J Physiol. 2006
Dec 31;49(6):283-9
40.
Chen WC, Liu SI, Hsu SS, Chang HT,
Huang JK, Jan CR*. Effect of riluzole on Ca2+
movement and cytotoxicity in Madin-Darby canine kidney cells. Hum
Exp Toxicol. 2006 Aug;25(8):461-9.
41.
Chang HC, Cheng HH, Huang CJ, Chen WC, Chen
IS, Liu SI, Hsu SS, Chang HT, Wang JK, Lu YC, Chou CT, Jan CR*.
Safrole-induced Ca2+ mobilization and cytotoxicity in
human PC3 prostate cancer cells. J Recept Signal Transduct Res.
2006;26(3):199-212.
42.
Yeh JH, Cheng HH, Huang CJ, Chung HM, Chiu HF,
Yang YL, Yeh MY, Chen WC, Kao CH, Chou CT, Jan CR*. Effect of
anandamide on cytosolic Ca2+ levels and proliferation in
canine renal tubular cells. Basic Clin Pharmacol Toxicol. 2006
Apr;98(4):416-22.
43.
Lin HC, Cheng HH, Huang CJ, Chen WC, Chen IS,
Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Lu YC, Jan CR*.
Safrole-induced cellular Ca2+ increases and death in
human osteosarcoma cells. Pharmacol
Res. 2006 Aug;54(2):103-10. Epub 2006 Mar 22.
44.
Tseng LL, Cheng HH, Huang CJ, Liu SI, Kuo CC,
Chen WC, Huang JK, Hsu SS, Chang HT, Kao CH, Ho CM, Jan CR*.
Dual effect of flurbiprofen on cell proliferation and
agonist-induced Ca2+ movement in human osteosarcoma
cells. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):160-7.
45.
Wang JL, Lin KL, Chen WC, Chou CT, Huang CJ,
Liu CS, Hsieh CH, Chang CH, Huang JK, Chang HT, Liu SI, Hsu SS, Jan
CR*. Effect of celecoxib on Ca2+ fluxes
and proliferation in MDCK renal tubular cells. J Recept Signal
Transduct Res. 2005;25(4-6):237-49.
46.
Huang JK, Cheng HH, Huang CJ, Kuo CC, Chen
WC, Liu SI, Hsu SS, Chang HT, Lu YC, Tseng LL, Chiang AJ, Chou CT, Jan
CR*. Effect of capsazepine on cytosolic Ca2+ levels
and proliferation of human prostate cancer cells. Toxicol In Vitro.
2006 Aug;20(5):567-74.
47.
Huang JK, Liu CS, Chen WC, Liu SI, Hsu SS,
Chang HT, Chou CT, Hsieh CH, Chang CH, Jan CR*. NPC-14686 (Fmoc-l-homophenylalanine)-induced
increases and death in human prostate cancer cells. Life Sci. 2006
Jan 25;78(9):964-9.
48.
Chang HT, Liu CS, Chou CT, Hsieh CH, Chang
CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Huang JK, Jan CR*.
Econazole induces increases in free intracellular Ca2+
concentrations in human osteosarcoma cells. Hum Exp Toxicol. 2005
Sep;24(9):453-8.
49.
Huang JK, Liu CS, Chou CT, Liu SI, Hsu SS,
Chang HT, Hsieh CH, Chang CH, Chen WC, Jan CR*. Effects of
econazole on Ca2+ levels and the growth of human prostate
cancer PC3 cells. Clin Exp Pharmacol Physiol. 2005 Sep;32(9):735-41.
50.
Huang JK, Huang CJ, Chen WC, Liu SI, Hsu SS,
Chang HT, Tseng LL, Chou CT, Chang CH, Jan CR*. Independent
[Ca2+]i increases and cell proliferation
induced by the carcinogen safrole in human oral cancer cells. Naunyn
Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):88-94.
51.
Wang JL, Liu CS, Lin KL, Chou CT, Hsieh CH,
Chang CH, Chen WC, Liu SI, Hsu SS, Chang HT, Jan CR*.
Nonylphenol-induced Ca2+ elevation and Ca2+-independent
cell death in human osteosarcoma cells. Toxicol Lett. 2005 Dec
30;160(1):76-83.
52.
Chang HT, Liu CS, Chou CT, Hsieh CH, Chang
CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Lu YC, Jan CR*.
Thimerosal-induced cytosolic Ca2+ elevation and
subsequent cell death in human osteosarcoma cells. Pharmacol Res.
2005; 52(4): 328-33.
53.
Jan CR*.
Effect of p-chloroamphetamine on calcium movement and viability in
renal tubular cells. Life Sci. 2005 Jun 17;77(5):589-99.
54.
Yeh JH, Huang CJ, Lee JW, Hsu SS, Chen JS,
Cheng HH, Chang HT, Huang JK, Chung HM, Yeh MY, Jan CR*. 2-O-methyl PAF as a Ca2+ mobilizer
in Madin Darby canine kidney cells. Life Sci. 2005, 77:336-344.
55.
Chang HT, Chen WC, Chen JS, Lu YC, Hsu SS,
Wang JL, Cheng HH, Cheng JS, Jiann BP, Chiang AJ, Huang JK, Jan
CR*. Effect of miconazole on intracellular Ca2+
levels and proliferation in human osteosarcoma cells. Life Sci.
2005;76:2091-101.
56.
Jan CR*,
Chen CH, Wang SC, Kuo SY. Effect of methylglyoxal on intracellular
calcium levels and viability in renal tubular cells. Cell Signal.
2005 Jul;17(7):847-55.
57.
Ho CM, Kuo SY, Chen CH, Huang JK, Jan CR*.
Effect of desipramine on [Ca2+]i levels and
growth in renal tubular cells. Cell Signal. 2005 Jul;17(7):837-45.
58.
Jan CR*,
Chao YY. Novel effect of Y-24180, a presumed specific
platelet-activating factor receptor antagonist, on Ca2+
levels and growth of human osteosarcoma cells. Pharmacol Res. 2005
Mar;51(3):189-95.
59.
Cheng HH, Ho CM, Huang CJ, Hsu SS, Jiann BP,
Chen JS, Huang JK, Chang HT, Lo YK, Yeh JH, Jan CR*. Defect
in regulation of Ca2+ movement in platelets from patients
with systemic lupus erythematosus. Pharmacology. 2005;73(4):169-74.
60.
Tseng LL, Huang CJ, Hsu SS, Chen JS, Cheng HH,
Chang HT, Jiann BP, Jan CR*.
Effect of calmidazolium on Ca2+ movement and
proliferation in human osteosarcoma cells. Clin Exp Pharmacol
Physiol. 2004 Oct;31(10):732-7.
61.
Hsu SS, Huang CJ, Chen JS, Cheng HH, Chang
HT, Jiann BP, Lin KL, Wang JL, Ho CM, Jan CR*. Effect of
nortriptyline on intracellular Ca2+ handling and
proliferation in human osteosarcoma cells. Basic Clin Pharmacol
Toxicol. 2004 Sep;95(3):124-30.
62.
Liu CP, Jan CR*. Effect of carvedilol
on Ca2+ movement and cytotoxicity in human MG63
osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004
Aug;95(2):59-65.
63.
Teng HP, Huang CJ, Yeh JH, Hsu SS, Lo YK,
Cheng JS, Cheng HH, Chen JS, Jiann BP, Chang HT, Huang JK, Jan CR*.
Capsazepine elevates intracellular Ca2+ in human
osteosarcoma cells, questioning its selectivity as a vanilloid
receptor antagonist. Life Sci. 2004 Oct 8;75(21):2515-26.
64.
Chou KJ, Jan CR*, Lee PT, Chen CL,
Chung HM, Hwang YY, Chou JD, Fang HC. Platelet hyperreactivity in
hemodialysis patients with frequently occluded vascular access.
Thromb Haemost. 2004 Sep;92(3):621-6.
65.
Huang JK, Chen WC, Huang CJ, Hsu SS, Chen JS,
Cheng HH, Chang HT, Jiann BP, Jan CR*.
Nordihydroguaiaretic
acid-induced Ca2+ handling and cytotoxicity in human
prostate cancer cells. Life Sci. 2004 Sep 24;75(19):2341-51.
66.
Hsu SS, Chen WC, Lo YK, Cheng JS, Yeh JH,
Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*.
Effect of the antidepressant maprotiline on Ca2+ movement
and proliferation in human prostate cancer cells. Clin Exp Pharmacol
Physiol. 2004 Jul;31(7):444-9.
67.
Hsu SS, Chen WC, Lo YK, Cheng JS, Liu CP,
Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*.
Effect of maprotiline on Ca2+ movement in human
neuroblastoma cells. Life Sci. 2004 Jul 16;75(9):1105-12
68.
Jan CR*,
Chao YY. Novel effect of Y-24180, a presumed specific platelet
activation factor receptor antagonist, on Ca2+ levels and
growth of human prostate cancer cells. Cell Signal. 2004
Aug;16(8):959-65.
69.
Hsu SS, Chen WC, Jiann BP, Chen JS, Huang JK,
Chang HT, Cheng HH, Lo YK, Ho CM, Jan CR*. Effect of the
antidepressant maprotiline on calcium movement and the viability of
renal tubular cells. Arch Toxicol. 2004 Aug;78(8):453-9.
Epub 2004 Apr 1
70.
Wang JL, Lin KL, Chen JS, Lu YC, Jiann BP,
Chang HT, Hsu SS, Chen WC, Huang JK, Ho CM, Jan CR*. Effect
of celecoxib on Ca2+ movement and cell proliferation in
human osteoblasts. Biochem Pharmacol. 2004 Mar 15;67(6):1123-30.
71.
Yeh JH, Chung HM, Ho CM, Jan CR*.
Mercury-induced Ca2+ increase and cytotoxicity in renal
tubular cells. Life Sci. 2004 Mar 5;74(16):2075-83.
72.
Chao YY, Jan CR*. Effect of Y-24180 on
Ca2+ movement and proliferation in renal tubular cells.
Life Sci 2004 Jan 2;74(7):923-33.
73.
Cheng JS, Lo YK, Yeh JH, Cheng HH, Liu CP, Chen WC, Jan CR*.
Effect of gossypol on intracellular Ca2+ regulation in
human hepatoma cells. Chin J Physiol. 2003 Sep 30;46(3):117-22.
74.
Chang HT, Hsu SS, Chen JS, Lin KL, Wang JL, Cheng HH, Lu
YC, Jiann
BP, Liu CP, Huang JK, Yeh JH, Chiang AJ, Chen WC, Jan CR*.
Effect of diethylstilbestrol on Ca2+ handling and cell
viability in human breast cancer cells. Chin J Physiol. 2003 Dec
31;46(4):187-92.
75.
Jan
CR*,
Lu YC, Tseng LL, Jiann
BP, Chang HT, Wang JL, Chen WC, Huang JK. Effect of the
antidepressant desipramine on cytosolic Ca2+ movement and
proliferation in human osteosarcoma cells. Pharmacology. 2003
Dec;69(4):190-6.
76.
Jan
CR*,
Jiann BP,
Lu YC, Chang HT, Yu CC, Chen
WC, Huang JK. Oxidation by thimerosal increases calcium levels in
renal tubular cells. Pharmacol Toxicol. 2003 Sep;93(3):123-7.
77.
Kuo SU, Ho CM, Chen WC, Jan CR*. Sulfhydryl
modification by 4,4'-dithiodipyridine induces calcium mobilization
in human osteoblast-like cells. Arch Toxicol. 2003 Nov;77(11):630-7.
Epub 2003 Aug 20.
78.
Jan
CR*,
Lu YC, Jiann BP, Chang HT, Wang JL, Chen WC, Huang JK. Novel effect
of n-palmitoyl-l-serine phosphoric acid on cytosolic Ca2+
levels in human osteoblasts. Pharmacol Toxicol. 2003;
Aug;93(2):71-6.
79.
Jan
CR*,
Kuo SY, Cheng JS, Lo YK, Liu CP, Chen WC. Effect of NPC-14686 (Fmoc-L-homophenylalanine)
on intracellular Ca2+ levels in human hepatoma cells.
Life Sci. 2003 Apr 25;72(23):2571-80.
80.
Jan
CR*,
Chiang AJ, Chang HT, Roan CJ, Lu YC, Jiann BP, Ho CM, Huang JK. The
anti-breast cancer drug tamoxifen alters Ca2+ movement in
Chinese hamster ovary (CHO-K1) cells. Arch Toxicol. 2003
Mar;77(3):160-6.
81.
Kuo SY, Jiann BP, Lu YC, Chang HT, Chen WC, Huang JK, Jan
CR*. Thiol oxidation by 2,2'-dithiodipyridine induced calcium
mobilization in MG63 human osteosarcoma cells. Life Sci. 2003 Feb
28;72(15):1733-43.
82.
Jan
CR*,
Jiann BP, Chang HT, Yu CC, Lu YC, Yeh JH, Chen WC, Law
YP,
Huang
JK. Effect of NPC-15199 on Ca2+ levels in renal tubular
cells. Chin J Physiol. 2002 Sep 30;45(3):117-22. Erratum in: Chin J
Physiol. 2003 Dec 31;45(4):200.
83.
Lu CH, Su W, Lo YK, Chen WC, Chang WN, Wang JL, Tsai YC, Lee
PY, Jan CR*. Effect of t-butyl hydroperoxide on Ca2+
movement in PC12 pheochromocytoma cells. Chin J Physiol. Jun 2002
Jun 30;45(2):51-6.
84.
Lu YC, Su W, Jiann BP, Chang HT, Huang JK, Jan CR*.
Effect of
(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)
cyclohexanol (CP55,940) on intracellular Ca2+ levels in
human osteosarcoma cells. Chin J Physiol. 2002 Sep 30;45(3):95-100.
Erratum in: Chin J Physiol. 2002 Dec 31;45(4):200.
85.
Liu CP, Chiang HT, Jan CR*. Novel effect of carvedilol
on Ca2+ movement in renal tubular cells. Biochem
Pharmacol. 2002 Dec 15;64 (12):1777-84.
86.
Jan
CR*,
Lu YC, Jiann BP, Chang HT, Su W, Chen WC, Huang JK. Novel effect of
CP55,940, a CB1/CB2 cannabinoid receptor agonist, on intracellular
free Ca2+ levels in bladder cancer cells. Chin J Physiol.
2002 Mar 31;45(1):33-9. Erratum in: Chin J Physiol. 2002 Dec
31;45(4):200.
87.
Jiann BP, Chou KJ, Chang HT, Chen WC, Huang JK, Jan CR*.
Effect of triethyltin on Ca2+ movement in Madin-Darby
canine kidney cells. Human Experi Toxicol. 2002;21:457-62.
88.
Jan
CR*,
Jiann BP, Lu YC, Chang HT, Huang JK. Effect of olvanil
(N-vanillyl-cis-9-octadecenoamide) on cytosolic Ca2+
increase in renal tubular cells. Life Sci. 2002 Nov
15;71(26):3081-90.
89.
Jan
CR*,
Lu
YC, Jiann
BP,
Chang HT, Huang
JK. Effect of riluzole on cytosolic Ca2+ handling in
human osteosarcoma cells. Pharmacology. 2002 Nov;66(3):120-7.
90.
Cheng JS, Jan CR*. Effect of nordihydroguaiaretic acid on
intracellular Ca2+ concentrations in hepatocytes. Toxicol
in Vitro. 2002 Oct;16(5):485-90.
91.
Lu YC, Jiann BP, Chang HT, Huang JK, Chen WC, Su W, Jan
CR*. Effect of the anti-breast cancer drug tamoxifen on Ca2+
movement in human osteosarcoma cells. Pharmacol Toxicol. 2002
Jul;91(1):34-9.
92.
Wang GJ, Lin LC, Chen CF, Cheng JS, Lo YK, Chou KJ, Lee KC,
Liu CP, Wu YY, Su W, Chen WC, Jan CR*. Effect of timosaponin
A-III, from Anemarrhenae asphodeloides Bunge (Liliaceae), on calcium
mobilization in vascular endothelial and smooth muscle cells and on
vascular tension. Life Sci. 2002 Jul 19;71(9):1081-90.
93.
Lin MC, Jan CR*. The anti-anginal drug fendiline
elevates cytosolic Ca2+ in rabbit corneal epithelial
cells. Life Sci. 2002 Jul 19;71(9):1071-9.
94.
Cheng JS, Liu CP, Lo YK, Chou KJ, Su W, Law YP, Chou KJ, Wang
JL, Chen WC, Jan CR*. Gossypol, a component in cottonseed,
induces increases in cytosolic Ca2+ levels in Chang liver
cells. Toxicon. 2002 Jul;40(7):851-6.
95.
Chao YY, Chen IS, Yeh JL, Chen JJ, Ko YC, Cheng JS, Liu CP,
Lo YK, Su W, Chou
KJ, Chen
WC, Jan
CR*. Novel
action of lignans isolated from Hernandia nymphaeifolia on Ca2+
signaling in renal tubular cells. Eur J Pharmacol. 2002 May
17;443(1-3):31-8.
96.
Jiann BP, Lu YC, Chang HT, Hunag JK, Jan CR*. Effect
of clomiphene on Ca2+ movement in human prostate cancer
cells. Life Sci. 2002 May 17;70(26):3167-78.
97.
Chao YY, Jan CR, Ko YC, Chen JJ, Jiann BP, Lu YC, Chen
WC, Su W, Chen IS. Effect of lignans isolated from Hernandia
nymphaeifolia on estrogenic compounds-induced calcium mobilization
in human neutrophils. Life Sci. 2002 May 17;70(26):3109-21.
98.
Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK,
Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect
of nordihydroguaiaretic acid on intracellular Ca2+
concentrations in C6 glioma cells. Neurochem Int. 2002
Mar;40(3):249-54.
99.
Jan
CR*,
Jiann BP, Lu YC, Chang HT, Su W, Chen WC, Yu CC, Huang JK. Effect of
the organotin compound triethyltin on Ca2+ handling in
human prostate cancer cells. Life Sci. 2002 Feb 1;70(11):1337-45.
100.
Chen WC, Cheng JS, Chou KJ, Tang KY, Huang JK, Tseng LL, Wang
JL, Lee KC, Jan CR*. Effect of 17beta-estradiol on
intracellular Ca2+ levels in renal tubular cells.
Pharmacology. 2002 Feb;64(2):84-90.
101.
Chang HT, Huang JK, Wang JL, Cheng JS, Lee KC, Lo YK, Liu CP,
Chou KJ, Chen WC, Su W, Law YP, Jan CR*. Tamoxifen-induced
increases in cytoplasmic free Ca2+ levels in human breast
cancer cells. Breast Cancer Res Treat. 2002 Jan;71(2):125-31.
102.
Chao YY, Su W, Jan CR*, Ko YC, Chen JJ, Cheng JS, Liu
CP, Lo YK, Chou KJ, Lee KC, Chen WC, Chen IS. Novel action of
lignans isolated from Hernandia nymphaeifolia on Ca2+
signaling in human neutrophils. Arch Toxicol.
2002Jan;75(11-12):695-702.
103.
Wang JL, Chang HT, Tseng LL, Liu CP, Lee KC, Chou KJ,
Cheng JS, Lo YK, Su W, Law YP, Chen WC, Chan RC, Jan CR*.
Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca2+.
Pharmacol Toxicol. 2001 Dec;89(6):301-5.
104.
Wang JW, Su W, Law YP, Lu CH, Chen YC, Wang JL, Chang HJ,
Chen WC, Jan CR*. Mechanism of bradykinin-induced Ca2+
mobilization in MG63 human osteosarcoma cells. Horm Res.
2001;55(6):265-70.
105.
Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee
KC, Lo YK, Chang HT, Huang JK, Jan CR*. Mechanism of
bifonazole-induced [Ca2+]i
increases in MDCK renal tubular cells. Chin J Physiol. 2001 Sep 30;44(3):97-101.
106.
Chen WC, Huang JK, Cheng JS, Tsai JC, Chiang AJ, Chou KJ, Liu
CP, Jan CR. AM-404 elevates renal intracellular Ca2+,
questioning its selectivity as a pharmacological tool for
investigating the anandamide transporter. J Pharmacol Toxicol
Methods. 2001 May-Jun;45(3):195-8.
107.
Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK,
Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect
of nordihydroguaiaretic acid on intracellular Ca2+
concentrations in C6 glioma cells. Neurochem Int. 2002 Mar;40(3):249-54.
108.
Lee KC, Chang HT, Chou KJ, Tang KY, Wang JL, Lo YK, Huang JK,
Chen WC, Su W, Law YP, Jan CR*. Mechanism underlying
histamine-induced intracellular Ca2+ movement in PC3
human prostate cancer cells. Pharmacol Res. 2001 Dec;44(6):547-52.
109.
Wu SN, Jan CR*, Chiang HT. Fenamates stimulate BKCa
channel osteoblast-like MG-63 cells activity in the human. J
Investig Med. 2001 Nov;49(6):522-33.
110.
Lo YK, Tang KY, Chang WN, Lu CH, Cheng JS, Lee KC, Chou KJ,
Liu CP, Chen WC, Su W, Law YP, Jan CR*. Effect of oleamide on
Ca2+ signaling in human bladder cancer cells. Biochem
Pharmacol. 2001 Nov 15;62(10):1363-9.
111.
Cheng JS, Chou KJ, Wang JL, Lee KC, Tseng LL, Tang KY, Huang
JK, Chang HT, Su W, Law YP, Jan CR*. Fendiline mobilizes
intracellular Ca2+ in Chang liver cells. Clin Exp
Pharmacol Physiol. 2001 Sep;28(9):729-33.
112.
Tseng CJ, Chan JY, Lo WC, Jan CR*. Modulation of
catecholamine release by endogenous adenosine in the rat adrenal
medulla. J Biomed Sci. 2001 Sep;8(5):389-94.
113.
Chou KJ, Tseng LL, Cheng JS, Wang JL, Fang HC, Lee K C, Su W,
Law YP, Jan CR*. CP55,940 increases intracellular Ca2+
levels in Madin-Darby canine kidney cells. Life Sci. 2001 Aug 17;69(13):1541-8.
114.
Cheng JS, Lee KC, Wang JL, Chang HT, Chou KJ, Tang KY, Jan CR*.
haracterization of histamine-induced increases in intracellular free
Ca2+ concentrations in Chang liver cells. J Recept Signal
Transduct Res. 2001 Feb;21(1):1-9.
115.
Chen YC, Wang JL, Liu CP, Cheng JS, Chang HT, Yuk-Keung L, Su
W, Law YP, Chen WC, Jan CR*. Clomiphene, an
ovulation-inducing agent, causes [Ca2+]i
increases in human osteoblast-like cells. Chin J Physiol. 2001 Jun
30;44(2):67-72.
116.
Cheng JS, Wang JL, Lo YK, Chou KJ, Lee KC, Liu CP, Chang HT, Jan
CR*. Effects of
the antianginal drug fendiline on Ca2+ movement in hepatoma cells.
Hum Exp Toxicol. 2001 Jul;20(7):359-64.
117.
Chen YC, Chen SJ, Chang HT, Huang JK, Wang JL, Tseng LL,
Chang HJ, Su W, Law YP, Chen WC, Jan CR*. Mechanisms of
diethylstilbestrol-induced calcium movement in MG63 human
osteosarcoma cells. Toxicol Lett. 2001 Jul 6;122(3):245-53.
118.
Jan
CR*,
Lee KC, Chou KJ, Cheng JS, Wang JL, Lo YK, Chang HT, Tang KY, Yu CC,
Huang JK. Fendiline, an anti-anginal drug, increases intracellular
Ca2+ in PC3 human prostate cancer cells. Cancer Chemother
Pharmacol. 2001 Jul;48(1):37-41.
119.
Wang JL, Lee KC, Tang KY, Lu T, Chang CH, Chow CK, Chen WC,
Su W, Law YP, Jan CR*. Effect of the neuroprotective agent riluzole on intracellular Ca2+
levels in IMR32 neuroblastoma cells. Arch Toxicol. 2001 Jun;75(4):214-20.
120.
Chen LW, Jan CR*.
Mechanisms and modulation of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced
Ca2+ mobilization in human neutrophils. Int
Immunopharmacol. 2001
Jul;1(7):1341-9.
121.
Chang HT, Huang JK, Wang JL, Cheng JS, Lee KC, Lo YK, Lin MC,
Tang KY, Jan CR*. Tamoxifen-Induced Ca2+ Mobilization in Bladder Female
Transitional Carcinoma Cells. Arch
Toxicol. 2001 May;75(3):184-8.
122.
Lo YK, Cheng JS, Wang JL, Lee KC, Chou KJ, Chang HT,
Tang KY, Jan CR*.
Fendiline-induced Ca2+ movement in A10 smooth muscle
cells. Chin J Physiol.
2001 Mar 31;44(1):19-24.
123.
Tang KY, Lu T, Chang CH, Lo YK, Cheng JS, Wang JL, Chang HT, Jan
CR*. Effect of fluoxetine on intracellular Ca2+
levels in bladder female transitional carcinoma (BFTC) cells. Pharmacol
Res. 2001 May;43(5):503-8.
124.
Chen LW, Jan CR*. Effect of the antianginal drug
bepridil on intracellular Ca2+ release and extracellular
Ca2+ influx in human neutrophils. Int Immunopharmacol. 2001 May;1(5):945-53.
125.
Lee KC, Tseng LL, Chen YC, Wang JW, Lu CH, Cheng JS, Wang JL,
Lo YK, Jan CR*. Mechanisms of histamine-induced intracellular
Ca2+ release and extracellular Ca2+ entry in MG63 human osteosarcoma
cells. Biochem Pharmacol. 2001 Jun 15;61(12):1537-41.
126.
Jan
CR*,
Yu CC, Huang JK. Dual effect of the antianginal drug fendiline on
bladder female transitional carcinoma cells: mobilization of
intracellular CA2+ and induction of cell death.
Pharmacology. 2001 May;62(4):218-23.
127.
Jan
CR*,
Yu CC, Huang JK. Clomiphene, an ovulation-inducing agent, mobilizes
intracellular Ca2+ and causes extracellular Ca2+
influx in bladder female transitional carcinoma cells. Horm Res.
2000;54(3):143-8.
128.
Huang JK, Jan CR*. Mechanism of estrogens-induced
increases in intracellular Ca2+ in PC3 human prostate
cancer cells. Prostate. 2001 May 15;47(3):141-8.
129.
Huang JK, Jan CR*. Linoleamide, a brain lipid that
induces sleep, increases cytosolic Ca2+ levels in MDCK
renal tubular cells. Life Sci. 2001 Jan 19;68(9):997-1004.
130.
Cheng JS, Lee KC, Wang JL, Tseng LL, Chou KJ, Tang KY, Jan
CR*. Histamine-Induced increases in intracellular free Ca2+
levels in hepatoma cells. Chin J Physiol. 2000 Dec 31;43(4):165-9.
131.
Huang
JK, Jan CR*. Linoleamide, a brain lipid that induces sleep,
increases cytosolic Ca2+ levels in MDCK renal tubular
cells. Life Sci. 2001 Jan 19;68(9):997-1004.
132.
Tang
KY, Cheng JS, Lee KC, Chou KJ, Huang JK, Chen WC, Jan CR*.
Fluoxetine-induced Ca2+ signals in Madin-Darby canine
kidney cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;363(1):16-20.
133.
Jan
CR*,
Cheng JS, Roan CJ, Lee KC, Chen WC, Chou KJ, Tang KY, Wang JL.
Effect of diethylstilbestrol (DES) on intracellular Ca2+ levels
in renal tubular cells. Steroids. 2001 Jun;66(6):505-10.
134.
Lee
KC, Chou KJ, Cheng JS, Wang JL, Tang KY, Tseng LL, Jan CR*.
Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase
inhibitor, on Ca2+ mobilization in Madin Darby canine
kidney cells. Pharmacol Toxicol. 2001 Jan;88(1):20-6.
135.
Wang
JL, Cheng JS, Chan RC, Tseng LL, Chou KJ, Tang KY, Lee KC, Lo YK,
Wang JW, Jan CR*. The anti-anginal drug fendiline increases
intracellular Ca2+ levels in MG63 human osteosarcoma
cells. Toxicol Lett. 2001;119:227-33.
136.
Chen
WC, Lin MC,
Chou
KJ, Fang
HC,
Liu CP, Cheng JS, Lo YK, Lee KC, Wang JL, Su W, Law YP, Jan CR*.
Novel
effects of a sleep-inducing lipid, oleamide, on Ca2+
signaling in renal tubular cells. Drug
Dev Res. 2001;54:40-4.
137.
Jan CR*, Yu CC, Huang JK.
Clomiphene, an ovulation-inducing agent, mobilizes intracellular Ca2+
and causes extracellular Ca2+ influx in bladder female
transitional carcinoma cells. Horm
Res. 2000;54(3):143-8.
138.
Cheng
JS, Lee KC, Wang JL, Tseng LL, Chou KJ, Tang KY, Jan CR*.
Histamine-induced increases in intracellular free Ca2+
levels in hepatoma cells. Chin
J Physiol. 2000 Dec 31;43(4):165-9.
139.
Jan
CR*,
Yu CC, Huang JK. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide
hydrochloride) (W-7) causes increases in intracellular free Ca2+
levels in bladder female transitional carcinoma (BFTC) cells.
Anticancer Res. 2000 Nov-Dec;20(6B):4355-9.
140.
Jan CR*, Wang JL, Lin MC, Lee
KC, Chou KJ, Chiang HT. Ca2+ mobilization induced by
delta-hexachlorocyclohexane in Madin Darby canine kidney cells. Drug
Dev Res. 2000;50:186-92.
141.
Huang
JK, Jan CR*. Intracellular calcium concentrations in human
bladder tumor cells could be increased by NPC-14686, a novel
anti-inflammatory agent. Drug Dev Res. 2000;50:147-52.
142.
Jan
CR*,
Chou KJ, Lee KC, Wang JL, Tseng LL, Cheng JS, Chen WC. Dual action
of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling:
activation of extracellular Ca2+ influx and alteration of
ATP- and bradykinin-induced Ca2+ responses in Madin Darby
canine kidney cells. Arch Toxicol. 2000 Oct;74(8):447-51.
143.
Lu
CH, Lee KC, Chen YC, Cheng JS, Yu MS, Chen WC, Jan CR*.
Lindane (gamma-hexachlorocyclohexane) induces internal Ca2+ release
and capacitative Ca2+ entry in Madin-Darby canine kidney
cells. Pharmacol Toxicol. 2000 Oct;87(4):149-55.
144.
Chen
LW, Jan CR*. Mechanisms underlying ATP-induced Ca2+
mobilization in human neutrophils. Shock. 2000 Nov;14(5):509-13.
145.
Jan
CR*,
Wang JL, Chou KJ, Cheng JS, Lee KC, Tseng LL, Wang SP, Tang KY,
Huang JK. NPC-14686, a novel anti-inflammatory agent, increased
intracellular Ca2+ concentrations in MDCK renal tubular
cells. Int J Immunopharmacol. 2000 Nov;22(11):915-21.
146.
Chou
KJ, Fang HC, Chung HM, Cheng JS, Lee KC, Tseng LL, Tang KY, Jan
CR*. Effect of betulinic acid on intracellular free Ca2+
levels in Madin Darby canine kidney cells. Eur J Pharmacol. 2000 Nov
17;408(2):99-106.
147.
Wu
SN, Jan CR*, Li HF, Chiang HT. Characterization of inhibition
by risperidone of the inwardly rectifying K+ current in
pituitary GH(3) cells. Neuropsychopharmacology. 2000 Dec;23(6):676-89.
148.
Jan
CR*,
Cheng JS, Chou KJ, Wang SP, Lee KC, Tang KY, Tseng LL, Chiang HT.
Dual effect of tamoxifen, an anti-breast-cancer drug, on
intracellular Ca2+ and cytotoxicity in intact cells. Toxicol Appl Pharmacol. 2000 Oct
1;168(1):58-63.
149.
Jan
CR*,
Lu CH, Chen YC, Cheng JS, Tseng LL, Jun-Wen W. Ca2+
mobilization induced by W-7 in MG63 human osteosarcoma cells.
Pharmacol Res. 2000 Oct;42(4):323-7.
150.
Wu
SN, Hwang T, Teng CM, Li HF, Jan CR. The mechanism of actions
of 3-(5'-(hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on Ca2+-activated
K+ currents in GH(3) lactotrophs. Neuropharmacology. 2000
Jul 24;39(10):1788-99.
151.
Jan CR*, Tseng CJ. MK-886, a leukotriene biosynthesis
inhibitor, as an activator of Ca2+ mobilization in Madin-Darby
canine kidney cells. J Pharmacol Exp Ther. 2000 Jul;294(1):96-102.
152.
Jan CR*, Yu CC, Huang JK. NPC-15199, a novel
anti-inflammatory agent, mobilizes intracellular Ca2+ in
bladder female transitional carcinoma cells. Chin J Physiol. 2000
Mar 31;43(1):29-33.
153.
Lo
WC, Jan CR, Chiang HT, Tseng CJ. Modulatory effects of carbon
monoxide on baroreflex activation in nucleus tractus solitarii of
rats. Hypertension. 2000 Jun;35(6):1253-7.
154.
Jan
CR*,
Tseng CJ, Chou KJ, Chiang HT. Novel effects of clotrimazole on Ca2+
signaling in Madin Darby canine kidney cells. Life Sci. 2000;66(23):2289-96.
155.
Jan CR*, Tseng CJ. Mechanisms of nordihydroguaiaretic
acid-induced [Ca2+]i increases in MDCK cells. Life Sci. 2000 Mar
24;66(18):1753-62.
156.
Jan CR*, Tseng CJ, Chou KJ, Chiang HT. Novel effects of
propranolol. Release of internal Ca2+ followed by
activation of capacitative Ca2+ entry In Madin Darby
canine kidney cells. Cell Signal. 2000 Apr;12(4):265-9.
157.
Jan CR*, Lin MC, Chou KJ, Huang JK. Novel effects of
gossypol, a hemical contraceptive in man: mobilization of internal
Ca2+ and activation of external Ca2+ entry in
intact cells. Biochim Biophys Acta. 2000 Apr 17;1496(2-3):270-6.
158.
Jan CR*, Tseng CJ, Chen WC. Fendiline increases [Ca2+]i in Madin Darby canine kidney cells by releasing
internal Ca2+ followed by capacitative Ca2+
entry. Life Sci. 2000;66(11):1053-62.
159.
Jan CR*, Chen LW, Lin MW. Ca2+ mobilization evoked
by chloroform in Madin-Darby canine kidney cells. J
Pharmacol Exp Ther. 2000 Mar;292(3):995-1001.
160.
Jan CR*, Tseng CJ. A novel
action of the antianginal drug bepredil: induction of internal Ca2+
release and external Ca2+ influx in Madin-Darby canine
kidney epithelial cells. Biochem Pharmacol. 2000 Mar
15;59(6):639-46.
161.
Jan CR*, Wang KY, Tseng CJ. Effect of sevoflurane on Ca2+
mobilization in Madin-Darby canine kidney cells. Biochem Pharmacol.
2000 Feb 15;59(4):393-400.
162.
Jan CR*, Tseng CJ.
Calmidazolium-induced rises in cytosolic calcium concentrations in
Madin Darby canine kidney cells. Toxicol Appl Pharmacol. 2000 Jan
15;162(2):142-50.
163.
Chen
WC, Cheng JS, Tsai JCR, Jan CR*. Calcium signals induced by
the endoplasmic reticulum Ca2+ pump inhibitior
cyclopiazonic acid in renal tubular cells. In Vitro & Mol
Toxicol. 2000;13:191-8.
164.
Jan CR*, Tseng CJ. Mechanisms
of miconazole-induced rise in cytoplasmic calcium concentrations in
Madin Darby canine kidney cells. Life Sci. 1999 Oct
29;65(23):2513-22.
165.
Jan CR*, Tseng CJ. W-7 induces
[Ca2+]i increases in Madin-Darby canine kidney
cells. J Pharmacol Exp Ther. 2000 Jan;292(1):358-65.
166.
Huang JK, Jan CR*.
AA-861-induced Ca2+ mobilization in Madin Darby canine
kidney cells. Toxicol Appl Pharmacol. 1999 Dec 1;161(2):202-8.
167.
Jan CR*, Wu SN, Tseng CJ. Zn2+
increases resting cytosolic Ca2+ levels and abolishes
capacitative Ca2+ entry induced by ATP in MDCK cells.
Naunyn Schmiedebergs Arch Pharmacol. 1999 Sep;360(3):249-55.
168.
Jan CR*, Wu SN, Tseng CJ. The
ether lipid ET-18-OCH3 increases cytosolic Ca2+
concentrations in Madin Darby canine kidney cells. Br J Pharmacol.
1999 Jul;127(6):1502-10.
169.
Wu
SN, Jan CR, Li HF. Ruthenium red-mediated inhibition of
large-conductance Ca2+-activated K+ channels
in rat pituitary GH3 cells. J Pharmacol Exp Ther. 1999 Sep;290(3):998-1005.
170.
Jan
CR,
Wu SN, Tseng CJ. A further investigation of ATP-induced calcium
mobilization in MDCK cells. Chin J Physiol. 1999 Mar 31;42(1):33-9.
171.
Jan CR*, Ho CM, Wu SN, Tseng
CJ. Multiple effects of
1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole
hydrochloride (SKF 96365) on Ca2+ signaling in MDCK
cells: depletion of thapsigargin-sensitive Ca2+ store
followed by capacitative Ca2+ entry, activation of a
direct Ca2+ entry, and inhibition of thapsigargin-induced
capacitative Ca2+ entry. Naunyn Schmiedebergs Arch
Pharmacol. 1999 Feb;359(2):92-101.
172.
Jan CR*, Ho CM, Wu SN, Tseng CJ. Mechanism of rise and
decay of thapsigargin-Evoked calcium signals in MDCK cells. Life Sci.
1999;64(4):259-67.
173.
Jan CR*, Ho CM, Wu SN, Tseng CJ. Multiple effects of
econazole on calcium signaling: depletion of thapsigargin-sensitive
calcium store, activation of extracellular calcium influx, and
inhibition of capacitative calcium entry. Biochim Biophys Acta. 1999
Jan 11;1448(3):533-42.
174.
Jan CR*, Ho CM, Wu SN, Tseng
CJ. Mechanism of rise and decay of
2,5-di-tert-butylhydroquinone-induced Ca2+ signals in
Madin Darby canine kidney cells. Eur J Pharmacol. 1999 Jan
15;365(1):111-7.
175.
Wu
SN, Jan CR, Li HF, Chen SA. Stimulation of large-conductance
Ca2+-activated K+ channels by Evans blue in
cultured endothelial cells of human umbilical veins. Biochem Biophys
Res Commun. 1999 Jan 27;254(3):666-74.
176.
Lo
WC, Jan CR, Wu SN, Tseng CJ. Cardiovascular effects of nitric
oxide and adenosine in the nucleus tractus solitarii of rats.
Hypertension. 1998 Dec;32(6):1034-8.
177.
Wu
SN, Li HF, Jan CR. Regulation of Ca2+-activated
nonselective cationic currents in rat pituitary GH3 cells:
involvement in L-type Ca2+ current. Brain Res. 1998 Nov
23;812(1-2):133-41.
178.
Wu
SN, Li HF, Jan CR, Chen IJ, Lo YC. Selective block by
glyceryl nonivamide of inwardly rectifying K+ current in
rat anterior pituitary GH3 cells. Life Sci. 1998;63(19):PL281-8.
179.
Li
HF, Shen AY, Jan CR, Wu SN. Co-activation of nonselective
cation channels by store depletion and oxidative stress in monocytic
U937 cells. Chin J Physiol. 1998 Jun 30;41(2):113-9.
180.
Jan CR*, Chen WC, Wu SN, Tseng
CJ. Nifedipine, verapamil and diltiazem block shock-wave-induced
rises in cytosolic calcium in MDCK cells. Chin J Physiol. 1998 Dec
31;41(4):181-8.
181.
Jan CR*, Ho CM, Wu SN, Tseng
CJ. Mechanisms of rise and decay of ADP-evoked calcium signal in
MDCK cells. Chin J Physiol. 1998 Jun 30;41(2):67-73.
182.
Jan CR*, Ho CM, Wu SN, Tseng
CJ. Bradykinin-evoked Ca2+ mobilization in Madin Darby
canine kidney cells. Eur J Pharmacol. 1998 Aug 21;355(2-3):219-33.
183.
Jan CR*, Ho CM, Wu SN, Tseng
CJ. The phospholipase C inhibitor U73122 increases cytosolic calcium
in MDCK cells by activating calcium influx and releasing stored
calcium. Life Sci. 1998;63(10):895-908.
184.
Wu
SN, Yu HS, Jan CR, Li HF, Yu CL. Inhibitory effects of
berberine on voltage- and calcium-activated potassium currents in
human myeloma cells. Life Sci. 1998;62(25):2283-94.
185.
Jan CR*, Ho CM, Wu SN, Huang JK,
Tseng CJ. La3+ inhibits UTP-induced Ca2+
mobilization in MDCK cells. Chin J Physiol. 1998;41(1):59-64.
186.
Jan CR*, Huang JK, Tseng CJ.
High-energy shock waves alter cytosolic calcium mobilization in
single MDCK cells. Nephron. 1998;78(2):187-94.
187.
Jan CR*, Ho CM, Wu SN, Huang JK,
Tseng CJ. Mechanism of lanthanum inhibition of extracellular
ATP-evoked calcium mobilization in MDCK cells. Life Sci.
1998;62(6):533-40.
188.
Wu SN, Jan CR, Li HF. Characteristics of
store-operated Ca(2+)-permeable current in monocytic U937 cells.
Chin J Physiol. 1997 Sep 30;40(3):115-20.
189.
Wu SN, Hwang TL, Jan CR, Tseng CJ. Ionic
mechanisms of tetrandrine in cultured rat aortic smooth muscle
cells. Eur J Pharmacol. 1997 May 30;327(2-3):233-8.
190.
Jan CR*, Chen WC, Lee YH, Huang
JK, Ou HC, Tseng CJ. Allopurinol blocks shock-wave-induced rises in
cytosolic calcium levels in MDCK cells. Urol Res. 1997;25(6):427-32.
191.
Chen WC, Jan CR*, Lee YH, Ou HC, Huang JK,
Tseng CJ. A model for investigating effect of shock waves on
intracellular calcium mobilization. Zhonghua Yi Xue Za Zhi (Taipei).
1996 Nov;58(5):341-7.
192.
Jan CR, Ribar TJ, Means AR,
Augustine GJ. Alterations in calcium channel currents underlie
defective insulin secretion in a transgenic Mouse. J Biol Chem. 1996
Jun 28;271(26):15478-85.
193.
Schneider AS, Jan CR. Na-Ca exchange in Ca2+
signaling and neurohormone secretion. Secretory vesicle
contributions in adrenal chromaffin cells. Ann N Y Acad Sci. 1996
Apr 15;779:356-65.
194.
Ribar
TJ, Jan CR, Augustine GJ, Means AR. Defective glycolysis and
calcium signaling underlie impaired insulin secretion in a
transgenic Mouse. J Biol Chem. 1995 Dec 1;270(48):28688-95.
195.
Jan
CR,
Schneider AS. Sodium-dependent calcium efflux from adrenal
chromaffin cells following exocytosis. Possible role of secretory
vesicle membranes. J Biol Chem. 1992 May 15;267(14):9695-700.
196.
Bigornia
L, Allen CN, Jan CR, Lyon RA, Titeler M, Schneider AS. D2
dopamine receptors modulate calcium channel currents and
catecholamine secretion in bovine adrenal chromaffin cells. J
Pharmacol Exp Ther. 1990 Feb;252(2):586-92.
197.
Jan CR, Titeler M, Schneider
AS. Identification of omega-conotoxin binding sites on adrenal
medullary membranes: possibility of multiple calcium channels in
chromaffin cells. J Neurochem. 1990 Jan;54(1):355-8.
198.Sadzot
B, Baraban JM, Glennon RA, Lyon RA, Leonhardt S, Jan CR,
Titeler M. Hallucinogenic drug interactions at human brain 5-HT2
receptors: implications for
treating
LSD-induced hallucinogenesis.
Psychopharmacology (Berl). 1989 98(4):495-9.
專書
1. 碩士論文：ATP對腎上腺嗜鉻細胞鈣離子吸收及腎上腺素分泌 之作用(1986)
2. 博士論文：腎上腺嗜鉻細胞鈣離子調控腎上腺素分泌 之機制(1992)
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