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學位           學校            國別         學門            年份______

博士後    美國北卡杜克大學     美國    神經生物暨藥理   1992/10-1994/12

博士      紐約州奧伯尼醫學院   美國         藥理        1987/8-1992/10

碩士         台灣大學        中華民國       農化        1984/8-1987/12

學士         台灣大學        中華民國       農化        1980/8-1983/6

經歷

2002/1-      高雄榮總教研部研究員

2001/7-      教育部頒定教授(教字第011594號)

2000/3-      輔英技術學院兼任教授

1997/8-      中山大學生物系兼任教授

1997/2-      教育部頒定副教授 (副字第025022號)

1996/8-      國防醫學院藥理系兼任副教授

1995/1-      高雄榮總教研部副研究員

 Research Interest:

利用螢光染料測定細胞內離子濃度之變化，及其與細胞功能之間的關係、所測之離子包括：鈣、氫和鈉，所用細胞為細胞株，實驗方法有二：１〕利用單一細胞，以數字化攝影（digital video imaging）測定。２〕利用懸浮細胞群（cell suspension）以螢光光譜儀（fluorescence spectrophotometer）測定。

利用西方點墨法(Western blot)研究細胞內有關訊息傳導路徑蛋白質（如MAPKs、STAT、PKC…）表現。利用流式細胞儀觀察藥物是否會誘導細胞產生細胞凋亡（apoptosis）。利用RT-PCR來偵測一些與鈣離子、鈣離子通道、發炎或細胞凋亡有關的基因表現。

Honour

1.       89年度行政院全國傑出研究獎

2.       89年度SCI總公司( ISI)台灣經典引文獎(2001.9.10)

3.       Reviewer of Journal of Neurochemistry (2001)

4.       Reviewer of Biochemical Pharmacology (2001)

5.       Reviewer of Life Sciences (2001)

6.       Reviewer of Journal of British Pharmacology (2003. Aug.)

7.       Reviewer of European Journal of Pain (2005, July)

8.       89年度榮清陽計畫年度報告壁報組第一名

9.       89年度中華藥理學會優秀論文獎

10.     88年度嚴慶齡基礎科學研究獎

11.   86, 88, 89, 92年度國科會甲種獎勵

Publication:.         

1.          Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP, Tseng PL, Kuo SJ, Jan CR*. Effects of antrodia camphorata on viability, apoptosis, and [Ca²⁺]_i in PC3 human prostate cancer cells.Chin J Physiol. 2008 Apr 30;51(2):78-84.

2.          Liao WC, Huang CC, Cheng HH, Wang JL, Lin KL, Cheng JS, Chai KL, Hsu PT, Tsai JY, Fang YC, Lu YC, Chang HT, Huang JK, Chou CT, Jan CR*. Effect of calmidazolium on [Ca²⁺]_i and viability in human hepatoma cells.Arch Toxicol. 2008 Jul 11. [Epub ahead of print]

3.          Chang HC, Huang CC, Huang CJ, Cheng JS, Liu SI, Tsai JY, Chang HT, Huang JK, Chou CT, Jan CR*. Desipramine-induced apoptosis in human PC3 prostate cancer cells: Activation of JNK kinase and caspase-3 pathways and a protective role of [Ca²⁺]_i elevation. Toxicology. 2008 Aug 19;250(1):9-14. Epub 2008 May 27.

4.          Hong-Tai Chang, Chorng-Chih Huang, He-Hsiung Cheng, Ti Lu, Jue-Long Wang, Ko-Long Lin, Pei-Te Hsu, Jeng-Yu Tsai, Wei-Chuan Liao, Yih-Chau Lu, Jong-Khing Huang, and Chung-Ren Jan*. Effects of MK-886, a Leukotriene Synthesis Inhibitor, on [Ca²⁺]_i and Apoptosis in MG63 Human Osteosarcoma Cells. Drug Dev Res 69：49-57(2008)

5.          Roan CJ, Huang CC, Cheng HH, Chien JM, Chou CT, Lin KL, Liu SI, Lu YC, Chang HT, Huang JK, Jan CR*. Diethylstilbestrol-Induced Estrogen Receptor-Dependent [Ca²⁺]_i Rises and Apoptosis in Chinese Hamster Ovary (CHO) Cells.J Recept Signal Transduct Res. 2008;28(3):307-22.

6.          Chang HT, Huang CC, Cheng HH, Wang JL, Lin KL, Hsu PT, Tsai JY, Liao WC, Lu YC, Huang JK, Jan CR*. Mechanisms of AM404-induced [Ca²⁺]_i rise and death in human osteosarcoma cells. Toxicol Lett. 2008 Jun 10;179(1):53-8. Epub 2008 Apr 11.

7.          Chu ST, Huang CC, Huang CJ, Cheng JS, Chai KL, Cheng HH, Fang YC, Chi CC, Su HH, Chou CT, Jan CR*. Tamoxifen-induced [Ca²⁺]_i rises and Ca2+-independent cell death in human oral cancer cells.J Recept Signal Transduct Res. 2007;27(5-6):353-67.

8.          Cheng JS, Huang CC, Chou CT, Jan CR*. Mechanisms of carvedilol-induced [Ca²⁺]_i rises and death in human hepatoma cells.Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):185-94. Epub 2007 Oct 5.

9.          Lu YC, Cheng HH, Huang CJ, Chu ST, Chi CC, Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Huang JK, Ho CM, Kuo SJ, Jan CR*. Effects of Antrodia Camphorata on Viability, Apoptosis, [Ca²⁺]_i, and MAPKs Phosphorylation in MG63 Human Osteosarcoma Cells. Drug Dev Res 2007; 68:71-8.pumed

10.      Lin MC, Huang CJ, Cheng HH, Chou CT, Wang JL, Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan CR*. Ketoconazole-evoked [Ca²⁺]_i rises and non-Ca²⁺-triggered cell death in rabbit corneal epithelial cell line (SIRC). J Recept Signal Transduct Res 2007;27(4):295-307.

11.      Liu SI, Huang CC, Huang CJ, Wang BW, Chang PM, Fang YC, Chen WC, Wang JL, Lu YC, Chu ST, Chou CT, Jan CR*. Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca²⁺]_i elevation. Toxicol Sci. 2007 Nov;100(1):109-17. Epub 2007 Aug 13.

12.      Chen WC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The carcinogen safrole increases intracellular free Ca²⁺ levels and causes death in MDCK cells. Chin J Physiol. 2007 Feb 28;50(1):34-40.

13.      Wang JL, Chan RC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Ho CM, Jan CR*. Short waves-induced enhancement of proliferation of human chondrocytes: involvement of extracellular signal-regulated MAP-Kinase (ERK). Clin Exp Pharmacol Physiol. 2007 Jul;34(7):581-5.

14.      Huang CJ, Cheng HH, Chou CT, Kuo CC, Lu YC, Tseng LL, Chiang AJ, Liu SI, Chen IS, Jan CR*. Desipramine-induced Ca²⁺ movement and cytotoxicity in PC3 human prostate cancer cells. Toxicol in Vitro. 2007 Apr;21(3):449-456. Epub 2006 Oct 27.

15.      Hsu SS, Huang CJ, Cheng HH, Chou CT, Lee HY, Wang JL, Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan CR*. Anandamide-induced Ca²⁺ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology. 2007 Feb 28;231(1):21-9. Epub 2006 Nov 11.

16.      Chou CT, He S, Jan CR*. Paroxetine-induced apoptosis in human osteosacroma cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca²⁺]_i elevation. Toxicol Appl Pharmacol. 2007 Feb 1;218(3):265-73. Epub 2006 Nov 15.

17.      Chu ST, Cheng HH, Huang CJ, Chang HC, Chi CC, Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Lu YC, Huang JK, Ho CM, Jan CR*. Phospholipase A₂-independent Ca²⁺ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells. Life Sci. 2007 Jan 2;80(4):364-369. Epub 2006 Sep 30.

18.      Pan CC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The antidepressant mirtazapine-induced cytosolic Ca²⁺ elevation and cytotoxicity in human osteosarcoma cells. Chin J Physiol. 2006 Dec 31;49(6):290-7.

19.      Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Wang JK, Lu YC, Jan CR*. Effect of nortriptyline on intracellular Ca²⁺ handling and proliferation in canine renal tubular cells. Chin J Physiol. 2006 Dec 31;49(6):283-9

20.      Chen WC, Liu SI, Hsu SS, Chang HT, Huang JK, Jan CR*. Effect of riluzole on Ca²⁺ movement and cytotoxicity in Madin-Darby canine kidney cells. Hum Exp Toxicol. 2006 Aug;25(8):461-9.

21.      Chang HC, Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Wang JK, Lu YC, Chou CT, Jan CR*. Safrole-induced Ca²⁺ mobilization and cytotoxicity in human PC3 prostate cancer cells. J Recept Signal Transduct Res. 2006;26(3):199-212.

22.      Yeh JH, Cheng HH, Huang CJ, Chung HM, Chiu HF, Yang YL, Yeh MY, Chen WC, Kao CH, Chou CT, Jan CR*. Effect of anandamide on cytosolic Ca²⁺ levels and proliferation in canine renal tubular cells. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):416-22.

23.      Lin HC, Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Lu YC, Jan CR*. Safrole-induced cellular Ca²⁺ increases and death in human osteosarcoma cells. Pharmacol Res. 2006 Aug;54(2):103-10. Epub 2006 Mar 22.

24.      Tseng LL, Cheng HH, Huang CJ, Liu SI, Kuo CC, Chen WC, Huang JK, Hsu SS, Chang HT, Kao CH, Ho CM, Jan CR*. Dual effect of flurbiprofen on cell proliferation and agonist-induced Ca²⁺ movement in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):160-7.

25.      Wang JL, Lin KL, Chen WC, Chou CT, Huang CJ, Liu CS, Hsieh CH, Chang CH, Huang JK, Chang HT, Liu SI, Hsu SS, Jan CR*. Effect of celecoxib on Ca²⁺ fluxes and proliferation in MDCK renal tubular cells. J Recept Signal Transduct Res. 2005;25(4-6):237-49.

26.      Huang JK, Cheng HH, Huang CJ, Kuo CC, Chen WC, Liu SI, Hsu SS, Chang HT, Lu YC, Tseng LL, Chiang AJ, Chou CT, Jan CR*. Effect of capsazepine on cytosolic Ca²⁺ levels and proliferation of human prostate cancer cells. Toxicol In Vitro. 2006 Aug;20(5):567-74.

27.      Huang JK, Liu CS, Chen WC, Liu SI, Hsu SS, Chang HT, Chou CT, Hsieh CH, Chang CH, Jan CR*. NPC-14686 (Fmoc-l-homophenylalanine)-induced increases and death in human prostate cancer cells. Life Sci. 2006 Jan 25;78(9):964-9.

28.      Chang HT, Liu CS, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Huang JK, Jan CR*. Econazole induces increases in free intracellular Ca²⁺ concentrations in human osteosarcoma cells. Hum Exp Toxicol. 2005 Sep;24(9):453-8.

29.      Huang JK, Liu CS, Chou CT, Liu SI, Hsu SS, Chang HT, Hsieh CH, Chang CH, Chen WC, Jan CR*. Effects of econazole on Ca²⁺ levels and the growth of human prostate cancer PC3 cells. Clin Exp Pharmacol Physiol. 2005 Sep;32(9):735-41.

30.      Huang JK, Huang CJ, Chen WC, Liu SI, Hsu SS, Chang HT, Tseng LL, Chou CT, Chang CH, Jan CR*. Independent [Ca²⁺]_i increases and cell proliferation induced by the carcinogen safrole in human oral cancer cells.Naunyn Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):88-94.

31.      Wang JL, Liu CS, Lin KL, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chang HT, Jan CR*. Nonylphenol-induced Ca²⁺ elevation and Ca²⁺-independent cell death in human osteosarcoma cells. Toxicol Lett. 2005 Dec 30;160(1):76-83.

32.      Chang HT, Liu CS, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Lu YC, Jan CR*. Thimerosal-induced cytosolic Ca²⁺ elevation and subsequent cell death in human osteosarcoma cells. Pharmacol Res. 2005; 52(4): 328-33.

33.      Jan CR*. Effect of p-chloroamphetamine on calcium movement and viability in renal tubular cells. Life Sci. 2005 Jun 17;77(5):589-99.

34.      Yeh JH, Huang CJ, Lee JW, Hsu SS, Chen JS, Cheng HH, Chang HT, Huang JK, Chung HM, Yeh MY, Jan CR*. 2-O-methyl PAF as a Ca²⁺ mobilizer in Madin Darby canine kidney cells. Life Sci. 2005, 77:336-344.

35.      Chang HT, Chen WC, Chen JS, Lu YC, Hsu SS, Wang JL, Cheng HH, Cheng JS, Jiann BP, Chiang AJ, Huang JK, Jan CR*. Effect of miconazole on intracellular Ca²⁺ levels and proliferation in human osteosarcoma cells. Life Sci. 2005;76:2091-101.

36.      Jan CR*, Chen CH, Wang SC, Kuo SY. Effect of methylglyoxal on intracellular calcium levels and viability in renal tubular cells. Cell Signal. 2005 Jul;17(7):847-55.

37.      Ho CM, Kuo SY, Chen CH, Huang JK, Jan CR*. Effect of desipramine on [Ca²⁺]_i levels and growth in renal tubular cells. Cell Signal. 2005 Jul;17(7):837-45.

38.      Jan CR*, Chao YY. Novel effect of Y-24180, a presumed specific platelet-activating factor receptor antagonist, on Ca²⁺ levels and growth of human osteosarcoma cells. Pharmacol Res. 2005 Mar;51(3):189-95.

39.      Cheng HH, Ho CM, Huang CJ, Hsu SS, Jiann BP, Chen JS, Huang JK, Chang HT, Lo YK, Yeh JH, Jan CR*. Defect in regulation of Ca²⁺ movement in platelets from patients with systemic lupus erythematosus. Pharmacology. 2005;73(4):169-74.

40.      Tseng LL, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR*.  Effect of calmidazolium on Ca²⁺ movement and proliferation in human osteosarcoma cells. Clin Exp Pharmacol Physiol. 2004 Oct;31(10):732-7.

41.      Hsu SS, Huang CJ, Chen JS, Cheng HH, Chang HT, Jiann BP, Lin KL, Wang JL, Ho CM, Jan CR*. Effect of nortriptyline on intracellular Ca²⁺ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004 Sep;95(3):124-30.

42.      Liu CP, Jan CR*. Effect of carvedilol on Ca²⁺ movement and cytotoxicity in human MG63 osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):59-65.

43.      Teng HP, Huang CJ, Yeh JH, Hsu SS, Lo YK, Cheng JS, Cheng HH, Chen JS, Jiann BP, Chang HT, Huang JK, Jan CR*. Capsazepine elevates intracellular Ca²⁺ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist. Life Sci. 2004 Oct 8;75(21):2515-26.

44.      Chou KJ, Jan CR*, Lee PT, Chen CL, Chung HM, Hwang YY, Chou JD, Fang HC. Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. Thromb Haemost. 2004 Sep;92(3):621-6.

45.      Huang JK, Chen WC, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR*.  Nordihydroguaiaretic acid-induced Ca²⁺ handling and cytotoxicity in human prostate cancer cells. Life Sci. 2004 Sep 24;75(19):2341-51.

46.      Hsu SS, Chen WC, Lo YK, Cheng JS, Yeh JH, Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*. Effect of the antidepressant maprotiline on Ca²⁺ movement and proliferation in human prostate cancer cells. Clin Exp Pharmacol Physiol. 2004 Jul;31(7):444-9.

47.      Hsu SS, Chen WC, Lo YK, Cheng JS, Liu CP, Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*. Effect of maprotiline on Ca²⁺ movement in human neuroblastoma cells. Life Sci. 2004 Jul 16;75(9):1105-12

48.      Jan CR*, Chao YY. Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca²⁺ levels and growth of human prostate cancer cells. Cell Signal. 2004 Aug;16(8):959-65.

49.      Hsu SS, Chen WC, Jiann BP, Chen JS, Huang JK, Chang HT, Cheng HH, Lo YK, Ho CM, Jan CR*. Effect of the antidepressant maprotiline on calcium movement and the viability of renal tubular cells. Arch Toxicol. 2004 Aug;78(8):453-9. Epub 2004 Apr 1

50.      Wang JL, Lin KL, Chen JS, Lu YC, Jiann BP, Chang HT, Hsu SS, Chen WC, Huang JK, Ho CM, Jan CR*. Effect of celecoxib on Ca²⁺ movement and cell proliferation in human osteoblasts. Biochem Pharmacol. 2004 Mar 15;67(6):1123-30.

51.      Yeh JH, Chung HM, Ho CM, Jan CR*. Mercury-induced Ca²⁺ increase and cytotoxicity in renal tubular cells. Life Sci. 2004 Mar 5;74(16):2075-83.

52.      Chao YY, Jan CR*. Effect of Y-24180 on Ca²⁺ movement and proliferation in renal tubular cells. Life Sci 2004 Jan 2;74(7):923-33.

53.      Cheng JS, Lo YK, Yeh JH, Cheng HH, Liu CP, Chen WC, Jan CR*. Effect of gossypol on intracellular Ca²⁺ regulation in human hepatoma cells. Chin J Physiol. 2003 Sep 30;46(3):117-22.

54.      Chang HT, Hsu SS, Chen JS, Lin KL, Wang JL, Cheng HH, Lu YC, Jiann BP, Liu CP, Huang JK, Yeh JH, Chiang AJ, Chen WC, Jan CR*. Effect of diethylstilbestrol on Ca²⁺ handling and cell viability in human breast cancer cells. Chin J Physiol. 2003 Dec 31;46(4):187-92.

55.      Jan CR*, Lu YC, Tseng LL, Jiann BP, Chang HT, Wang JL, Chen WC, Huang JK. Effect of the antidepressant desipramine on cytosolic Ca²⁺ movement and proliferation in human osteosarcoma cells. Pharmacology. 2003 Dec;69(4):190-6.

56.      Jan CR*, Jiann BP, Lu YC, Chang HT, Yu CC, Chen WC, Huang JK. Oxidation by thimerosal increases calcium levels in renal tubular cells. Pharmacol Toxicol. 2003 Sep;93(3):123-7.

57.      Kuo SU, Ho CM, Chen WC, Jan CR*. Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells. Arch Toxicol. 2003 Nov;77(11):630-7. Epub 2003 Aug 20.

58.      Jan CR*, Lu YC, Jiann BP, Chang HT, Wang JL, Chen WC, Huang JK. Novel effect of n-palmitoyl-l-serine phosphoric acid on cytosolic Ca²⁺ levels in human osteoblasts. Pharmacol Toxicol. 2003; Aug;93(2):71-6.

59.      Jan CR*, Kuo SY, Cheng JS, Lo YK, Liu CP, Chen WC. Effect of NPC-14686 (Fmoc-L-homophenylalanine) on intracellular Ca²⁺ levels in human hepatoma cells. Life Sci. 2003 Apr 25;72(23):2571-80.

60.      Jan CR*, Chiang AJ, Chang HT, Roan CJ, Lu YC, Jiann BP, Ho CM, Huang JK. The anti-breast cancer drug tamoxifen alters Ca²⁺ movement in Chinese hamster ovary (CHO-K1) cells. Arch Toxicol. 2003 Mar;77(3):160-6.

61.      Kuo SY, Jiann BP, Lu YC, Chang HT, Chen WC, Huang JK, Jan CR*. Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells. Life Sci. 2003 Feb 28;72(15):1733-43.

62.      Jan CR*, Jiann BP, Chang HT, Yu CC, Lu YC, Yeh JH, Chen WC, Law YP, Huang JK. Effect of NPC-15199 on Ca²⁺ levels in renal tubular cells. Chin J Physiol. 2002 Sep 30;45(3):117-22. Erratum in: Chin J Physiol. 2003 Dec 31;45(4):200.

63.      Lu CH, Su W, Lo YK, Chen WC, Chang WN, Wang JL, Tsai YC, Lee PY, Jan CR*. Effect of t-butyl hydroperoxide on Ca²⁺ movement in PC12 pheochromocytoma cells. Chin J Physiol. Jun 2002 Jun 30;45(2):51-6.

64.      Lu YC, Su W, Jiann BP, Chang HT, Huang JK, Jan CR*.  Effect of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP55,940) on intracellular Ca²⁺ levels in human osteosarcoma cells. Chin J Physiol. 2002 Sep 30;45(3):95-100. Erratum in: Chin J Physiol. 2002 Dec 31;45(4):200.

65.      Liu CP, Chiang HT, Jan CR*. Novel effect of carvedilol on Ca²⁺ movement in renal tubular cells. Biochem Pharmacol. 2002 Dec 15;64 (12):1777-84.

66.      Jan CR*, Lu YC, Jiann BP, Chang HT, Su W, Chen WC, Huang JK. Novel effect of CP55,940, a CB1/CB2 cannabinoid receptor agonist, on intracellular free Ca²⁺ levels in bladder cancer cells. Chin J Physiol. 2002 Mar 31;45(1):33-9. Erratum in: Chin J Physiol. 2002 Dec 31;45(4):200.

67.      Jiann BP, Chou KJ, Chang HT, Chen WC, Huang JK, Jan CR*. Effect of triethyltin on Ca²⁺ movement in Madin-Darby canine kidney cells. Human Experi Toxicol. 2002;21:457-62.

68.      Jan CR*, Jiann BP, Lu YC, Chang HT, Huang JK. Effect of olvanil (N-vanillyl-cis-9-octadecenoamide) on cytosolic Ca²⁺ increase in renal tubular cells. Life Sci. 2002 Nov 15;71(26):3081-90.

69.      Jan CR*, Lu YC, Jiann BP, Chang HT, Huang JK. Effect of riluzole on cytosolic Ca²⁺ handling in human osteosarcoma cells. Pharmacology. 2002 Nov;66(3):120-7.

70.      Cheng JS, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca²⁺ concentrations in hepatocytes. Toxicol in Vitro. 2002 Oct;16(5):485-90.

71.      Lu YC, Jiann BP, Chang HT, Huang JK, Chen WC, Su W, Jan CR*. Effect of the anti-breast cancer drug tamoxifen on Ca²⁺ movement in human osteosarcoma cells. Pharmacol Toxicol. 2002 Jul;91(1):34-9.

72.      Wang GJ, Lin LC, Chen CF, Cheng JS, Lo YK, Chou KJ, Lee KC, Liu CP, Wu YY, Su W, Chen WC, Jan CR*. Effect of timosaponin A-III, from Anemarrhenae asphodeloides Bunge (Liliaceae), on calcium mobilization in vascular endothelial and smooth muscle cells and on vascular tension. Life Sci. 2002 Jul 19;71(9):1081-90.

73.      Lin MC, Jan CR*. The anti-anginal drug fendiline elevates cytosolic Ca²⁺ in rabbit corneal epithelial cells. Life Sci. 2002 Jul 19;71(9):1071-9.

74.      Cheng JS, Liu CP, Lo YK, Chou KJ, Su W, Law YP, Chou KJ, Wang JL, Chen WC, Jan CR*. Gossypol, a component in cottonseed, induces increases in cytosolic Ca²⁺ levels in Chang liver cells. Toxicon. 2002 Jul;40(7):851-6.

75.      Chao YY, Chen IS, Yeh JL, Chen JJ, Ko YC, Cheng JS, Liu CP, Lo YK, Su W, Chou KJ, Chen WC, Jan CR*. Novel action of lignans isolated from Hernandia nymphaeifolia on Ca²⁺ signaling in renal tubular cells. Eur J Pharmacol. 2002 May 17;443(1-3):31-8.

76.      Jiann BP, Lu YC, Chang HT, Hunag JK, Jan CR*. Effect of clomiphene on Ca²⁺ movement in human prostate cancer cells. Life Sci. 2002 May 17;70(26):3167-78.

77.      Chao YY, Jan CR, Ko YC, Chen JJ, Jiann BP, Lu YC, Chen WC, Su W, Chen IS. Effect of lignans isolated from Hernandia nymphaeifolia on estrogenic compounds-induced calcium mobilization in human neutrophils. Life Sci. 2002 May 17;70(26):3109-21.

78.      Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK, Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca²⁺ concentrations in C6 glioma cells. Neurochem Int. 2002 Mar;40(3):249-54.

79.      Jan CR*, Jiann BP, Lu YC, Chang HT, Su W, Chen WC, Yu CC, Huang JK. Effect of the organotin compound triethyltin on Ca²⁺ handling in human prostate cancer cells. Life Sci. 2002 Feb 1;70(11):1337-45.

80.      Chen WC, Cheng JS, Chou KJ, Tang KY, Huang JK, Tseng LL, Wang JL, Lee KC, Jan CR*. Effect of 17beta-estradiol on intracellular Ca²⁺ levels in renal tubular cells. Pharmacology. 2002 Feb;64(2):84-90.

81.      Chang HT, Huang JK, Wang JL, Cheng JS, Lee KC, Lo YK, Liu CP, Chou KJ, Chen WC, Su W, Law YP, Jan CR*. Tamoxifen-induced increases in cytoplasmic free Ca²⁺ levels in human breast cancer cells. Breast Cancer Res Treat. 2002 Jan;71(2):125-31.

82.      Chao YY, Su W, Jan CR*, Ko YC, Chen JJ, Cheng JS, Liu CP, Lo YK, Chou KJ, Lee KC, Chen WC, Chen IS. Novel action of lignans isolated from Hernandia nymphaeifolia on Ca²⁺ signaling in human neutrophils. Arch Toxicol. 2002Jan;75(11-12):695-702.

83.      Wang JL, Chang HT, Tseng LL, Liu CP, Lee KC, Chou KJ, Cheng JS, Lo YK, Su W, Law YP, Chen WC, Chan RC, Jan CR*. Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca²⁺. Pharmacol Toxicol. 2001 Dec;89(6):301-5.

84.      Wang JW, Su W, Law YP, Lu CH, Chen YC, Wang JL, Chang HJ, Chen WC, Jan CR*. Mechanism of bradykinin-induced Ca²⁺ mobilization in MG63 human osteosarcoma cells. Horm Res. 2001;55(6):265-70.

85.      Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee KC, Lo YK, Chang HT, Huang JK, Jan CR*. Mechanism of bifonazole-induced [Ca²⁺]_i increases in MDCK renal tubular cells.Chin J Physiol. 2001 Sep 30;44(3):97-101.

86.      Chen WC, Huang JK, Cheng JS, Tsai JC, Chiang AJ, Chou KJ, Liu CP, Jan CR. AM-404 elevates renal intracellular Ca²⁺, questioning its selectivity as a pharmacological tool for investigating the anandamide transporter. J Pharmacol Toxicol Methods. 2001 May-Jun;45(3):195-8.

87.      Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK, Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca²⁺ concentrations in C6 glioma cells. Neurochem Int. 2002 Mar;40(3):249-54.

88.      Lee KC, Chang HT, Chou KJ, Tang KY, Wang JL, Lo YK, Huang JK, Chen WC, Su W, Law YP, Jan CR*. Mechanism underlying histamine-induced intracellular Ca²⁺ movement in PC3 human prostate cancer cells.Pharmacol Res. 2001 Dec;44(6):547-52.

89.      Wu SN, Jan CR*, Chiang HT. Fenamates stimulate BKCa channel osteoblast-like MG-63 cells activity in the human. J Investig Med. 2001 Nov;49(6):522-33.

90.      Lo YK, Tang KY, Chang WN, Lu CH, Cheng JS, Lee KC, Chou KJ, Liu CP, Chen WC, Su W, Law YP, Jan CR*. Effect of oleamide on Ca²⁺ signaling in human bladder cancer cells. Biochem Pharmacol. 2001 Nov 15;62(10):1363-9.

91.      Cheng JS, Chou KJ, Wang JL, Lee KC, Tseng LL, Tang KY, Huang JK, Chang HT, Su W, Law YP, Jan CR*. Fendiline mobilizes intracellular Ca²⁺ in Chang liver cells. Clin Exp Pharmacol Physiol. 2001 Sep;28(9):729-33.

92.      Tseng CJ, Chan JY, Lo WC, Jan CR*. Modulation of catecholamine release by endogenous adenosine in the rat adrenal medulla. J Biomed Sci. 2001 Sep;8(5):389-94.

93.      Chou KJ, Tseng LL, Cheng JS, Wang JL, Fang HC, Lee K C, Su W, Law YP, Jan CR*. CP55,940 increases intracellular Ca²⁺ levels in Madin-Darby canine kidney cells. Life Sci. 2001 Aug 17;69(13):1541-8.

94.      Cheng JS, Lee KC, Wang JL, Chang HT, Chou KJ, Tang KY, Jan CR*. haracterization of histamine-induced increases in intracellular free Ca²⁺ concentrations in Chang liver cells. J Recept Signal Transduct Res. 2001 Feb;21(1):1-9.

95.      Chen YC, Wang JL, Liu CP, Cheng JS, Chang HT, Yuk-Keung L, Su W, Law YP, Chen WC, Jan CR*. Clomiphene, an ovulation-inducing agent, causes [Ca²⁺]_i increases in human osteoblast-like cells. Chin J Physiol. 2001 Jun 30;44(2):67-72.