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TNM and Stage Groupings > Anus
Anus
Primary Tumor (T)
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
| Tis |
Carcinoma in situ (Bowen’s disease, High-grade Squamous Intraepithelial
Lesion (HSIL), Anal Intraepithelial Neoplasia II-III (AIN II-III) |
| T1 |
Tumor 2 cm or less in greatest dimension |
| T2 |
Tumor more than 2 cm but not more than 5 cm in greatest dimension |
| T3 |
Tumor more than 5 cm in greatest dimension |
| T4 |
Tumor of any size invades adjacent organ(s), e.g., vagina, urethra, bladder* |
*Direct invasion of the rectal wall, perirectal skin, subcutaneous tissue, or the sphincter
muscle(s) is not classified as T4.
Regional Lymph Nodes (N)
| N Category |
Stage Category Definitions |
| NX |
Regional lymph nodes cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Metastasis in perirectal lymph node(s) |
| N2 |
Metastasis in unilateral internal iliac and/or inguinal lymph node(s) |
| N3 |
Metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac
and/or inguinal lymph nodes |
Distant Metastasis (M)
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
Anatomic Stage/Prognostic Groups
| Stage |
T |
N |
M |
| 0 |
Tis |
N0 |
M0 |
| I |
T1 |
N0 |
M0 |
| II |
T2 |
N0 |
M0 |
| II |
T3 |
N0 |
M0 |
| IIIA |
T1 |
N1 |
M0 |
| IIIA |
T2 |
N1 |
M0 |
| IIIA |
T3 |
N1 |
M0 |
| IIIA |
T4 |
N0 |
M0 |
| IIIB |
T4 |
N1 |
M0 |
| IIIB |
Any T |
N2 |
M0 |
| IIIB |
Any T |
N3 |
M0 |
| IV |
Any T |
Any N |
M1 |
