TNM and Stage Groupings

1. Head and Neck
• Lip and Oral Cavity (Nonepithelial tumors such as those of lymphoid tissue, soft tissue, bone, cartilage, and mucosal melanoma are not included)
• Pharynx (Including base of tongue, soft palate, and uvula) (Nonepithelial tumors such as those of lymphoid tissue, soft tissue, bone, cartilage, and mucosal melanoma are not included)
• Larynx (Nonepithelial tumors such as those of lymphoid tissue, soft tissue, bone, cartilage, and mucosal melanoma are not included)
• Nasal Cavity and Paranasal Sinuses (Nonepithelial tumors such as those of lymphoid tissue, soft tissue, bone, cartilage, and mucosal melanoma are not included)
• Major Salivary Glands (Parotid, submandibular, and sublingual)
• Thyroid
• Mucosal Melanoma of the Head and Neck
2. Digestive System
• Esophagus and Esophagogastric Junction (Nonmucosal cancers are not included)
• Stomach (Lymphomas, sarcomas, and carcinoid tumors [low-grade neuroendocrine tumors] are not included.)
• Small Intestine (Lymphomas, carcinoid tumors, and visceral sarcomas are not included)
• Appendix (Carcinomas and carcinoid tumors of the appendix are included, but separately categorized)
• Colon and Rectum (Sarcomas, lymphomas, and carcinoid tumors of the large intestine are not included.)
• Anus (The classification applies to carcinomas only; melanomas, carcinoid tumors, and sarcomas are not included.)
• Gastrointestinal Stromal Tumor
• Neuroendocrine Tumors (Gastric, small bowel, colonic, rectal, and ampulla of vater carcinoid tumors [well-differentiated neuroendocrine tumors and well-differentiated neuroendocrine carcinomas]; carcinoid tumors of the appendix and neuroendocrine tumors of the pancreas are not included.)
• Liver (Excluding intrahepatic bile ducts; sarcomas and tumors metastatic to the liver are not included)
• Intrahepatic Bile Ducts (Sarcomas and tumors metastatic to the liver are not included)
• Gallbladder (Carcinoid tumors and sarcomas are not included)
• Perihilar Bile Ducts (Sarcomas and carcinoid tumors are not inculded)
• Distal Bile Duct (Sarcoma and carcinoid tumors are not inculded)
• Ampulla of Vater (Well-differentiated neuroendocrine [carcinoid tumors] are not included)
• Exocrine and Endocrine Pancreas
3. Thorax
• Lung (Carcinoid tumors are included. Sarcomas and other rare tumors are not included.)
• Pleural Mesothelioma (Peritoneal and pericardial mesotheliomas are rare and do not lend themselves easily to a TNM staging system)
4. Musculoskeletal Sites
• Bone (Primary malignant lymphoma and multiple myeloma are not included.)
• Soft Tissue Sarcoma (Kaposi's sarcoma, fibromatosis [desmoid tumor], and sarcoma arising from the dura mater, brain, parenchymatous organs, or hollow viscera are not included.)
5. Skin
• Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas (eyelid is not included)
• Merkel Cell Carcinoma (Merkel cell carcinoma of the eyelid is not included)
• Melanoma of the Skin
6. Breast
• Breast
7. Gynecologic Sites
• Vulva (Mucosal malginant melanoma is not included)
• Vagina
• Cervix Uteri
• Corpus Uteri
  • Corpus Uteri Carcinoma (Carcinosarcomas should be staged as carcinomas)
  • Corpus Uteri Sarcoma (Carcinosarcomas should be staged as carcinomas)
• Ovary and Primary Peritoneal Carcinoma
• Fallopian Tube
• Gestational Trophoblastic Tumors
8. Genitourinary Sites
• Penis (Primary urethral carcinomas and melanomas are not included)
• Prostate (Sarcomas and transitional cell carcinomas are not included)
• Testis
• Kidney
• Renal Pelvis and Ureter
• Urinary Bladder
• Urethra
• Adrenal
9. Ophthalmic Sites
• Carcinoma of the Eyelid
• Carcinoma of the Conjunctiva
• Malignant Melanoma of the Conjunctiva
• Malignant Melanoma of the Uvea
• Retinoblastoma
• Carcinoma of the Lacrimal Gland
• Sarcoma of the Orbit
• Ocular Adnexal Lymphoma
10. Central Nervous System
• Brain and Spinal Cord
11. Lymphoid Neoplasms
• Hodgkin and Non-Hodgkin Lymphomas (Excludes ocular adnexal lymphoma)
• Primary Cutaneous Lymphomas
• Multiple Myeloma and Plasma Cell Disorders
• Pediatric Lymphoid Malignancy