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Lung

Primary Tumor (T)
T Category Stage Category Definitions
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ
T1 Tumor ≦ 3 cm in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus)*
T1a Tumor ≦ 2 cm in greatest dimension
T1b Tumor > 2 cm but ≦ 3 cm in greatest dimension
T2 Tumor > 3 cm but ≦ 7 cm or tumor with any of the following features (T2 tumors with these features are classified T2a if ≦ 5 cm)
Involves main bronchus, ≧ 2 cm distal to the carina
Invades visceral pleura (PL1 or PL2)
Associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung
T2a Tumor > 3 cm but ≦ 5 cm in greatest dimension
T2b Tumor > 5 cm but ≦ 7 cm in greatest dimension
T3 Tumor > 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (< 2 cm distal to the carina* but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe
T4 Tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, separate tumor nodule(s) in a different ipsilateral lobe
* The uncommon superficial spreading tumor of any size with its invasive component limited to the bronchial wall, which may extend proximally to the main bronchus, is also classified as T1a.

Regional Lymph Nodes (N)
N Category Stage Category Definitions
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension
N2 Metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s)
N3 Metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)

Distant Metastasis (M)
M Category Stage Category Definitions
M1 Distant metastasis
M1a Separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion**
M1b Distant metastasis
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
**Most pleural (and pericardial) effusions with lung cancer are due to tumor. In a few patients, however, multiple cytopathologic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and is not an exudate. Where these elements and clinical judgement dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging element and the patient should be classified as M0.

Anatomic Stage/Prognostic Groups
Stage T N M
Occult TX N0 M0
0 Tis N0 M0
IA T1a N0 M0
IA T1b N0 M0
IB T2a N0 M0
IIA T2b N0 M0
IIA T1a N1 M0
IIA T1b N1 M0
IIA T2a N1 M0
IIB T2b N1 M0
IIB T3 N0 M0
IIIA T1a N2 M0
IIIA T1b N2 M0
IIIA T2a N2 M0
IIIA T2b N2 M0
IIIA T3 N1 M0
IIIA T3 N2 M0
IIIA T4 N0 M0
IIIA T4 N1 M0
IIIB T1a N3 M0
IIIB T1b N3 M0
IIIB T2a N3 M0
IIIB T2b N3 M0
IIIB T3 N3 M0
IIIB T4 N2 M0
IIIB T4 N3 M0
IV Any T Any N M1a
IV Any T Any N M1b