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Pleural Mesothelioma

Primary Tumor (T)
T Category Stage Category Definitions
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
T1 Tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement
T1a No involvement of the visceral pleura
T1b Tumor also involving the visceral pleura
T2 Tumor involving each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following features:
‧ involvement of diaphragmatic muscle
‧ extension of tumor from visceral pleura into the underlying pulmonary parenchyma
T3 Locally advanced but potentially resectable tumor
Tumor involving all of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following features:
‧ involvement of the endothoracic fascia
‧ extension into the mediastinal fat
‧ solitary, completely resectable focus of tumor extending into the soft tissues of the chest wall
‧ non-transmural involvement of the pericardium
T4 Locally advanced technically unresectable tumor
Tumor involving all of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following features:
‧ diffuse extension or multifocal masses of tumor in the chest wall, with or without associated rib destruction
‧ direct transdiaphragmatic extension of tumor to the peritoneum
‧ direct extension of tumor to the contralateral pleura
‧ direct extension of tumor to mediastinal organs
‧ direct extension of tumor into the spine
‧ tumor extending through to the internal surface of the pericardium with or without a pericardial effusion; or tumor involving the myocardium
IMIG Staging System for Diffuse Malignant Pleural Mesothelioma (MPM)

Regional Lymph Nodes (N)
N Category Stage Category Definitions
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastases
N1 Metastases in the ipsilateral bronchopulmonary or hilar lymph nodes
N2 Metastases in the subcarinal or the ipsilateral mediastinal lymph nodes including the ipsilateral internal mammary and peridiaphragmatic nodes
N3 Metastases in the contralateral mediastinal, contralateral internal mammary, ipsilateral or contralateral supraclavicular lymph nodes

Distant Metastasis (M)
M Category Stage Category Definitions
M1 Distant metastasis
No distant metastasis (no pathologic M0; use clinical M to complete stage group)

Anatomic Stage/Prognostic Groups
Stage T N M
I T1 N0 M0
IA T1a N0 M0
IB T1b N0 M0
II T2 N0 M0
III T1, T2 N1 M0
III T1, T2 N2 M0
III T3 N0, N1, N2 M0
IV T4 Any N M0
IV Any T N3 M0
IV Any T Any N M1