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TNM and Stage Groupings > Neuroendocrine Tumor
Neuroendocrine Tumor
Primary Tumor (T) - Stomach
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
| Tis |
Carcinoma in situ/dysplasia (tumor size < 0.5mm), confined to mucosa |
| T1 |
Tumor invades lamina propria or submucosa and ≦ 1cm in size |
| T2 |
Tumor invades muscularis propria or > 1cm in size |
| T3 |
Tumor penetrates subserosa |
| T4 |
Tumor invades visceral peritoneum (serosa) or other organs or adjacent
structures |
For any T, add (m) for multiple tumors
Primary Tumor (T) - Duodenum/Ampulla/Jejunum/Ileum
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
| T1 |
Tumor invades lamina propria or submucosa and size ≦ 1 cm * (small intestinal
tumors); tumor ≦ 1 cm (ampullary tumors) |
| T2 |
Tumor invades muscularis propria or size > 1 cm (small intestinal tumors); tumor > 1 cm (ampullary tumors) |
| T3 |
Tumor invades through the muscularis propria into subserosal tissue without
penetration of overlying serosa (jejunal or ileal tumors) or invades pancreas
or retroperitoneum (ampullary or duodenal tumors ) or into non-
peritonealized tissues. |
| T4 |
Tumor invades visceral peritoneum (serosa) or invades other organs |
For any T, add (m) for multiple tumors
*Tumor limited to ampulla of Vater for ampullary gangliocytic paraganglioma
Primary Tumor (T) - Colon or Rectum
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
| T1 |
Tumor invades lamina propria or submucosa and size ≦ 2 cm |
| T1a |
Tumor size < 1 cm in greatest dimension |
| T1b |
Tumor size 1 to 2 cm in greatest dimension |
| T2 |
Tumor invades muscularis propria or size > 2 cm with invasion of lamina propria
or submucosa |
| T3 |
Tumor invades through the muscularis propria into the subserosa, or into non -
peritonealized pericolic or perirectal tissues |
| T4 |
Tumor invades peritoneum or other organs |
For any T, add (m) for multiple tumors
Regional Lymph Nodes (N) - Stomach
| N Category |
Stage Category Definitions |
| NX |
Regional lymph nodes cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Regional lymph node metastasis |
Regional Lymph Nodes (N) - Duodenum/Ampulla/Jejunum/Ileum
| N Category |
Stage Category Definitions |
| NX |
Regional lymph nodes cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Regional lymph node metastasis |
Regional Lymph Nodes (N) - Colon or Rectum
| N Category |
Stage Category Definitions |
| NX |
Regional lymph nodes cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Regional lymph node metastasis |
Distant Metastasis (M) - Stomach
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
Distant Metastasis (M) - Duodenum/Ampulla/Jejunum/Ileum
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
Distant Metastasis (M) - Colon or Rectum
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
Anatomic Stage/Prognostic Groups
| Stage |
T |
N |
M |
| 0 |
Tis* |
N0 |
M0 |
| I |
T1 |
N0 |
M0 |
| IIA |
T2 |
N0 |
M0 |
| IIB |
T3 |
N0 |
M0 |
| IIIA |
T4 |
N0 |
M0 |
| IIIB |
Any T |
N1 |
M0 |
| IV |
Any T |
Any N |
M1 |
