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TNM and Stage Groupings > Prostate
Prostate
Primary Tumor (T)
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
| pT2 |
Organ confined |
| pT2a |
Unilateral, one-half of one side or less |
| pT2b |
Unilateral, involving more than one-half of side but not both sides |
| pT2c |
Bilateral disease |
| pT3 |
Extraprostatic extension |
| pT3a |
Extraprostatic extension or microscopic invasion of bladder neck *** |
| pT3b |
Seminal vesicle invasion |
| pT4 |
Invasion of rectum, levator muscles and/or pelvic wall |
Note: There is no pathologic T1 classification.
*Note: Tumor found in one or both lobes by needle biopsy, but not palpable or reliably
visible by imaging, is classified as T1c.
**Note: Invasion into the prostatic apex or into (but not beyond) the prostatic capsule is
classified not as T3 but as T2.
***Note: Positive surgical margin should be indicated by an R1 descriptor (residual
microscopic disease).
Regional Lymph Nodes (N)
| N Category |
Stage Category Definitions |
| pNX |
Regional nodes not sampled |
| pN0 |
No positive regional nodes |
| pN1 |
Metastases in regional node(s) |
Distant Metastasis (M)
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
| M1a |
Non-regional lymph node(s) |
| M1b |
Bone(s) |
| M1c |
Other site(s) with or without bone disease |
*Note: When more than one site of metastasis is present, the most advanced category
is used. pM1c is most advanced
Anatomic Stage/Prognostic Groups
| Stage |
T |
N |
M |
PSA |
Gleason |
| I |
T1a-c |
N0 |
M0 |
PSA < 10 |
Gleason ≦ 6 |
| I |
T2a |
N0 |
M0 |
PSA < 10 |
Gleason ≦ 6 |
| I |
T1-2a |
N0 |
M0 |
PSA X |
Gleason X |
| IIA |
T1a-c |
N0 |
M0 |
PSA < 20 |
Gleason 7 |
| IIA |
T1a-c |
N0 |
M0 |
PSA ≧ 10 < 20 |
Gleason ≦ 6 |
| IIA |
T2a |
N0 |
M0 |
PSA < 20 |
Gleason ≦ 7 |
| IIA |
T2b |
N0 |
M0 |
PSA < 20 |
Gleason ≦ 7 |
| IIA |
T2b |
N0 |
M0 |
PSA X |
Gleason X |
| IIB |
T2c |
N0 |
M0 |
Any PSA |
Any Gleason |
| IIB |
T1-2 |
N0 |
M0 |
PSA ≧ 20 |
Any Gleason |
| IIB |
T1-2 |
N0 |
M0 |
Any PSA |
Gleason ≧ 8 |
| III |
T3a-b |
N0 |
M0 |
Any PSA |
Any Gleason |
| IV |
T4 |
N0 |
M0 |
Any PSA |
Any Gleason |
| IV |
Any T |
N1 |
M0 |
Any PSA |
Any Gleason |
| IV |
Any T |
Any N |
M1 |
Any PSA |
Any Gleason |
*When either PSA or Gleason is not available, grouping should be determined
by T stage and/or either PSA or Gleason as available.
