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Stomach

Primary Tumor (T)
T Category Stage Category Definitions
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria
T1 Tumor invades lamina propria, muscularis mucosae, or submucosa
T1a Tumor invades lamina propria or muscularis mucosae
T1b Tumor invades submucosa
T2 Tumor invades muscularis propria
T3 Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures*,**,***
T4 Tumor invades serosa (visceral peritoneum) or adjacent structures**,***
T4a Tumor invades serosa (visceral peritoneum)
T4b Tumor invades adjacent structures
*A tumor may penetrate the muscularis propria with extension into the gastrocolic or gastrohepatic ligaments, or into the greater or lesser omentum, without perforation of the visceral peritoneum covering these structures. In this case, the tumor is classified T3. If there is perforation of the visceral peritoneum covering the gastric ligaments or the omentum, the tumor should be classified T4.
**The adjacent structures of the stomach include the spleen, transverse colon, liver, diaphragm, pancreas, abdominal wall, adrenal gland, kidney, small intestine, and retroperitoneum.
***Intramural extension to the duodenum or esophagus is classified by the depth of the greatest invasion in any of these sites, including the stomach.

Regional Lymph Nodes (N)
N Category Stage Category Definitions
NX Regional lymph node(s) cannot be assessed
N0 No regional lymph node metastasis*
N1 Metastasis in 1 to 2 regional lymph nodes
N2 Metastasis in 3 to 6 regional lymph nodes
N3 Metastasis in 7 or more regional lymph nodes
N3a Metastasis in 7 to15 regional lymph nodes
N3b Metastasis in 16 or more regional lymph nodes
* A designation of pN0 should be used if all examined lymph nodes are negative, regardless of the total number removed and examined.

Distant Metastasis (M)
M Category Stage Category Definitions
M1 Distant metastasis
No distant metastasis (no pathologic M0; use clinical M to complete stage group)

Anatomic Stage/Prognostic Groups
Stage T N M
0 Tis N0 M0
IA T1 N0 M0
IB T2 N0 M0
IB T1 N1 M0
IIA T3 N0 M0
IIA T2 N1 M0
IIA T1 N2 M0
IIB T4a N0 M0
IIB T3 N1 M0
IIB T2 N2 M0
IIB T1 N3 M0
IIIA T4a N1 M0
IIIA T3 N2 M0
IIIA T2 N3 M0
IIIB T4b N0 M0
IIIB T4b N1 M0
IIIB T4a N2 M0
IIIB T3 N3 M0
IIIC T4b N2 M0
IIIC T4b N3 M0
IIIC T4a N3 M0
IV Any T Any N M1