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Urethra

Primary Tumor (T) (male and female)
T Category Stage Category Definitions
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Ta Non-invasive papillary, polypoid, or verrucous carcinoma
Tis Carcinoma in situ
T1 Tumor invades subepithelial connective tissue
T2 Tumor invades any of the following: corpus spongiosum, prostate, periurethral muscle
T3 Tumor invades any of the following: corpus cavernosum, beyond prostatic capsule, anterior vagina, bladder neck
T4 Tumor invades other adjacent organs

Primary Tumor (T ) - Urothelial Carcinoma of the Prostate
T Category Stage Category Definitions
Tis pu Carcinoma in situ, involvement of the prostatic urethra
Tis pd Carcinoma in situ, involvement of the prostatic ducts
T1 Tumor invades urethral subepithelial connective tissue
T2 Tumor invades any of the following: prostatic stroma, corpus spongiosum, periurethral muscle
T3 Tumor invades any of the following: corpus cavernosum, beyond prostatic capsule, bladder neck (extraprostatic extension)
T4 Tumor invades other adjacent organs (invasion of the bladder)

Regional Lymph Nodes (N)
N Category Stage Category Definitions
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in a single lymph node 2 cm or less in greatest dimension
N2 Metastasis in a single node more than 2 cm in greatest dimension, or in multiple nodes

Distant Metastasis (M)
M Category Stage Category Definitions
M1 Distant metastasis
No distant metastasis (no pathologic M0; use clinical M to complete stage group)

Anatomic Stage/Prognostic Groups
Stage T N M
0a Ta N0 M0
0is Tis N0 M0
0is Tis pu N0 M0
0is Tis pd N0 M0
I T1 N0 M0
II T2 N0 M0
III T1 N1 M0
III T2 N1 M0
III T3 N0 M0
III T3 N1 M0
IV T4 N0 M0
IV T4 N1 M0
IV Any T N2 M0
IV Any T Any N M1