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TNM and Stage Groupings > Malignant Melanoma of the Uvea
Malignant Melanoma of the Uvea
Primary Tumor (T) - All Uveal Melanomas
| T Category |
Stage Category Definitions |
| TX |
Primary tumor cannot be assessed |
| T0 |
No evidence of primary tumor |
Primary Tumor (T) - Iris*
| T Category |
Stage Category Definitions |
| T1 |
Tumor limited to the iris |
| T1a |
Tumor limited to the iris not more than 3 clock hours in size |
| T1b |
Tumor limited to the iris more than 3 clock hours in size |
| T1c |
Tumor limited to the iris with secondary glaucoma |
| T2 |
Tumor confluent with or extending into the ciliary body, choroid or both |
| T2a |
Tumor confluent with or extending into the ciliary body, choroid or both,
with secondary glaucoma |
| T3 |
Tumor confluent with or extending into the ciliary body, choroid or both, with
scleral extension |
| T3a |
Tumor confluent with or extending into the ciliary body, choroid or both, with
scleral extension and secondary glaucoma |
| T4 |
Tumor with extrascleral extension |
| T4a |
Tumor with extrascleral extension less than or equal to 5 mm in diameter |
| T4b |
Tumor with extrascleral extension more than 5 mm in diameter |
* Iris melanomas originate from, and are predominantly located in, this region of
the uvea. If less than half of the tumor volume is located within the iris, the
tumor may have originated in the ciliary body and consideration should be
given to classifying it accordingly.
Primary Tumor (T) - Ciliary Body and Choroid
| T Category |
Stage Category Definitions |
| T1 |
Tumor size category 1 |
| T1a |
Tumor size category 1 without ciliary body involvement and extraocular
extension |
| T1b |
Tumor size category 1 with ciliary body involvement |
| T1c |
Tumor size category 1 without ciliary body involvement but with extraocular
extension less than or equal to 5 mm in diameter |
| T1d |
Tumor size category 1 with ciliary body involvement and extraocular
extension less than or equal to 5 mm in diameter |
| T2 |
Tumor size category 2 |
| T2a |
Tumor size category 2 without ciliary body involvement and extraocular
extension |
| T2b |
Tumor size category 2 with ciliary body involvement |
| T2c |
Tumor size category 2 without ciliary body involvement but with extraocular
extension less than or equal to 5 mm in diameter |
| T2d |
Tumor size category 2 with ciliary body involvement and extraocular
extension less than or equal to 5 mm in diameter |
| T3 |
Tumor size category 3 |
| T3a |
Tumor size category 3 without ciliary body involvement and extraocular
extension |
| T3b |
Tumor size category 3 with ciliary body involvement |
| T3c |
Tumor size category 3 without ciliary body involvement but with extraocular
extension less than or equal to 5 mm in diameter |
| T3d |
Tumor size category 3 with ciliary body involvement and extraocular
extension less than or equal to 5 mm in diameter |
| T4 |
Tumor size category 4 |
| T4a |
Tumor size category 4 without ciliary body involvement and extraocular
extension |
| T4b |
Tumor size category 4 with ciliary body involvement |
| T4c |
Tumor size category 4 without ciliary body involvement but with extraocular
extension less than or equal to 5 mm in diameter |
| T4d |
Tumor size category 4 with ciliary body involvement and extraocular
extension less than or equal to 5 mm in diameter |
| T4e |
Any tumor size category with extraocular extension more than 5 mm in
diameter |
Pathologic: When histopathologic measurements are recorded after fixation,
tumor diameter and thickness may be underestimated because of tissue shrinkage.
Regional Lymph Nodes (N)
| N Category |
Stage Category Definitions |
| NX |
Regional lymph nodes cannot be assessed |
| N0 |
No regional lymph node metastasis |
| N1 |
Regional lymph node metastasis |
Distant Metastasis (M)
| M Category |
Stage Category Definitions |
| M1 |
Distant metastasis |
| M1a |
Largest diameter of the largest metastasis ≦ 3 cm |
| M1b |
Largest diameter of the largest metastasis 3.1-8.0 cm |
| M1c |
Largest diameter of the largest metastasis ≧ 8 cm |
No distant metastasis (no pathologic M0; use clinical M to complete stage group)
Anatomic Stage/Prognostic Groups
| Stage |
T |
N |
M |
| I |
T1a |
N0 |
M0 |
| IIA |
T1b-d |
N0 |
M0 |
| IIA |
T2a |
N0 |
M0 |
| IIB |
T2b |
N0 |
M0 |
| IIB |
T3a |
N0 |
M0 |
| IIIA |
T2c-d |
N0 |
M0 |
| IIIA |
T3b-c |
N0 |
M0 |
| IIIA |
T4a |
N0 |
M0 |
| IIIB |
T3d |
N0 |
M0 |
| IIIB |
T4b-c |
N0 |
M0 |
| IIIC |
T4d-e |
N0 |
M0 |
| IV |
Any T |
N1 |
M0 |
| IV |
Any T |
Any N |
M1a-c |
