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WHO classification of tumors of hematopoietic and lymphoid tissues

Myeloproliferative neoplasms

Chronic myelogenous leukemia, BCR-ABL1 positive - ICD-O 9875/3
Chronic neutrophilic leukemia - ICD-O 9963/3
Polycythemia vera - ICD-O 9950/3
Primary myelofibrosis - ICD-O 9961/3
Essential thrombocythemia - ICD-O 9962/3
Chronic eosinophilic leukemia, NOS - ICD-O 9964/3
Mastocytosis

Cutaneous mastocytosis - ICD-O 9740/1
Systemic mastocytosis - ICD-O 9741/3
Mast cell leukemia - ICD-O 9742/3
Mast cell sarcoma - ICD-O 9740/3
Extracutaneous mastocytoma - ICD-O 9740/1

Myeloproliferative neoplasm, unclassifiable - ICD-O 9975/3

Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1

Myeloid and lymphoid neoplasms with PDGFRA rearrangement - ICD-O 9965/3
Myeloid neoplasms with PDGFRB rearrangement - ICD-O 9966/3
Myeloid and lymphoid neoplasms with FGFR1 abnromalities - ICD-O 9967/3

Myelodysplastic/Myeloproliferative neoplasms

Chronic myelomonocytic leukemia - ICD-O 9945/3
Atypical chronic myeloid leukemia, BCR-ABL1 negative - ICD-O 9876/3
Juvenile myelomonocytic leukemia - ICD-O 9946/3
Myelodysplastic/myeloproliferative neoplasm, unclassifiable - ICD-O 9975/3

Refractory anemia with ring sideroblasts associated with marked thrombocytosis - ICD-O 9982/3

Myelodysplastic syndromes

Refractory cytopenia with unilineage dysplasia

Refractory anemia - ICD-O 9980/3
Refractory neutropenia - ICD-O 9991/3
Refractory thrombocytopenia - ICD-O 9992/3

Refractory anemia with ring sideroblasts - ICD-O 9982/3
Refractory cytopenia with multilineage dysplasia - ICD-O 9985/3
Refractory anemia with excess blasts - ICD-O 9983/3
Myelodysplastic syndrome associated with isolated del(5q) - ICD-O 9986/3
Myelodysplastic syndrome, unclassifiable - ICD-O 9989/3
Childhood myelodysplastic syndrome

Refractory cytopenia of childhood - ICD-O 9985/3

Acute myeloid leukemia (AML) and related precursor neoplasms

AML with recurrent genetic abnormalities

AML with t(8;21)(q22;q22); RUNX1-RUNX1T1 - ICD-O 9896/3
AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 - ICD-O 9871/3
Acute promyelocytic leukemia with t(15;17)(q22;q12); PML-RARA - ICD-O 9866/3
AML with t(9;11)(p22;q23); MLLT3-MLL - ICD-O 9897/3
AML with t(6;9)(p23;q34); DEK-NUP214 - ICD-O 9865/3
AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 - ICD-O 9869/3
AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 - ICD-O 9911/3
AML with mutated NPM1 - ICD-O 9861/3
AML with mutated CEBPA - ICD-O 9861/3

AML with myelodysplasia-related changes - ICD-O 9895/3
Therapy-related myeloid neoplasms - ICD-O 9920/3
Acute myeloid leukemia, NOS - ICD-O 9861/3

AML with minimal differentiation - ICD-O 9872/3
AML without maturation - ICD-O 9873/3
AML with maturation - ICD-O 9874/3
Acute myelomonocytic leukemia - ICD-O 9867/3
Acute monoblastic and monocytic leukemia - ICD-O 9891/3
Acute erythroid leukemia - ICD-O 9840/3
Acute megakaryoblastic leukemia - ICD-O 9910/3
Acute basophilic leukemia - ICD-O 9870/3
Acute panmyelosis with myelofibrosis - ICD-O 9931/3

Myeloid sarcoma - ICD-O 9930/3

Myeloid proliferations related to Down syndrome

Transient abnormal myelopoiesis - ICD-O 9898/1
Myeloid leukemia associated with Down syndrome - ICD-O 9898/3

Blastic plasmacytoid dendritic cell neoplasm - ICD-O 9727/3

Acute leukemias of ambiguous lineage

Acute undifferentiated leukemia - ICD-O 9801/3
Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1 - ICD-O 9806/3
Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged - ICD-O 9807/3
Mixed phenotype acute leukemia, B/myeloid, NOS - ICD-O 9808/3
Mixed phenotype acute leukemia, T/myeloid, NOS - ICD-O 9809/3
Natural killer (NK) cell lymphoblastic leukemia/lymphoma

Precursor lymphoid neoplasms

B lymphoblastic leukemia/lymphoma

B lymphoblastic leukemia/lymphoma, NOS - ICD-O 9811/3
B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities

B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1 - ICD-O 9812/3
B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged - ICD-O 9813/3
B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) - ICD-O 9814/3
B lymphoblastic leukemia/lymphoma with hyperdiploidy - ICD-O 9815/3
B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL) - ICD-O 9816/3
B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32); IL3-IGH - ICD-O 9817/3
B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) - ICD-O 9818/3

T lymphoblastic leukemia/lymphoma - ICD-O 9837/3

Mature B-cell neoplasms

Chronic lymphocytic leukemia/small lymphocytic lymphoma - ICD-O 9823/3
B-cell prolymphocytic leukemia - ICD-O 9833/3
Splenic B-cell marginal zone lymphoma - ICD-O 9689/3
Hairy cell leukemia - ICD-O 9940/3
Splenic B-cell lymphoma/leukemia, unclassifiable - ICD-O 9591/3

Splenic diffuse red pulp small B-cell lymphoma - ICD-O 9591/3
Hairy cell leukemia-variant - ICD-O 9591/3

Lymphoplasmacytic lymphoma - ICD-O 9671/3

Waldenstrom macroglobulinemia - ICD-O 9761/3

Heavy chain diseases - ICD-O 9762/3

Alpha heavy chain disease - ICD-O 9762/3
Gamma heavy chain disease - ICD-O 9762/3
Mu heavy chain disease - ICD-O 9762/3

Plasma cell neoplasms

Monoclonal gammopathy of undetermined significance - ICD-O 9765/1
Plasma cell myeloma - ICD-O 9732/3
Solitary plasmacytoma of bone - ICD-O 9731/3
Extraosseous plasmacytoma - ICD-O 9734/3

Primary amyloidosis - ICD-O 9769/1
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) - ICD-O 9699/3
Nodal marginal zone lymphoma - ICD-O 9699/3

Pediatric nodal marginal zone lymphoma - ICD-O 9699/3

Follicular lymphoma - ICD-O 9690/3

Grade 1 - ICD-O 9695/3
Grade 2 - ICD-O 9691/3
Grade 3A - ICD-O 9698/3
Grade 3B - ICD-O 9698/3
Pediatric follicular lymphoma - ICD-O 9690/3

Primary cutaneous follicle centre lymphoma - ICD-O 9597/3
Mantle cell lymphoma - ICD-O 9673/3
Diffuse large B-cell lymphoma (DLBCL), NOS - ICD-O 9680/3

T-cell/histiocyte-rich large B-cell lymphoma - ICD-O 9688/3
Primary DLBCL of the CNS - ICD-O 9680/3
Primary cutaneous DLBCL, leg type - ICD-O 9680/3
EBV positive DLBCL of the elderly - ICD-O 9680/3

DLBCL associated with chronic inflammation - ICD-O 9680/3
Lymphomatoid granulomatosis - ICD-O 9766/1
Primary mediastinal (thymic) large B-cell lymphoma - ICD-O 9679/3
Intravascular large B-cell lymphoma - ICD-O 9712/3
ALK positive large B-cell lymphoma - ICD-O 9737/3
Plasmablastic lymphoma - ICD-O 9735/3
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease - ICD-O 9738/3
Primary effusion lymphoma - ICD-O 9678/3
Burkitt lymphoma - ICD-O 9687/3
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma - ICD-O 9680/3
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma - ICD-O 9596/3

Mature T-cell and NK-cell neoplasms

T-cell prolymphocytic leukemia - ICD-O 9834/3
T-cell large granular lymphocytic leukemia - ICD-O 9831/3
Chronic lymphoproliferative disorders of NK-cells - ICD-O 9831/3
Aggressive NK-cell leukemia - ICD-O 9948/3
Systemic EBV-positive T-cell lymphoproliferative disease of childhood - ICD-O 9724/3
Hydroa vacciniforme-like lymphoma - ICD-O 9725/3
Adult T-cell leukemia/lymphoma - ICD-O 9827/3
Extranodal NK/T cell lymphoma, nasal type - ICD-O 9719/3
Enteropathy-associated T-cell lymphoma - ICD-O 9717/3
Hepatosplenic T-cell lymphoma - ICD-O 9716/3
Subcutaneous panniculitis-like T-cell lymphoma - ICD-O 9708/3
Mycosis fungoides - ICD-O 9700/3
Sezary syndrome - ICD-O 9701/3
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders

Lymphomatoid papulosis - ICD-O 9718/1
Primary cutaneous anaplastic large cell lymphoma - ICD-O 9718/3

Primary cutaneous gamma-delta T-cell lymphoma - ICD-O 9726/3
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma - ICD-O 9709/3
Primary cutaneous CD4-positive small/medium T-cell lymphoma - ICD-O 9709/3
Peripheral T-cell lymphoma, NOS - ICD-O 9702/3
Angioimmunoblastic T-cell lymphoma - ICD-O 9705/3
Anaplastic large cell lymphoma, ALK-positive - ICD-O 9714/3
Anaplastic large cell lymphoma, ALK-negative - ICD-O 9702/3

Hodgkin lymphoma

Nodular lymphocyte predominant Hodgkin lymphoma - ICD-O 9659/3
Classical Hodgkin lymphoma - ICD-O 9650/3

Nodular sclerosis classical Hodgkin lymphoma - ICD-O 9663/3
Lymphocyte-rich classical Hodgkin lymphoma - ICD-O 9651/3
Mixed cellularity classical Hodgkin lymphoma - ICD-O 9652/3
Lymphocyte-depleted classical Hodgkin lymphoma - ICD-O 9653/3

Histiocytic and dendritic cell neoplasms

Histiocytic sarcoma - ICD-O 9755/3
Langerhans cell histiocytosis - ICD-O 9751/3
Langerhans cell sarcoma - ICD-O 9756/3
Interdigitating dendritic cell sarcoma - ICD-O 9757/3
Follicular dendritic cell sarcoma - ICD-O 9758/3
Fibroblastic reticular cell tumor - ICD-O 9759/3
Indeterminate dendritic cell tumor - ICD-O 9757/3
Disseminated juvenile xanthogranuloma

Post-transplant lymphoproliferative disorders (PTLD)

Early lesions

Plasmacytic hyperplasia - ICD-O 9971/1
Infectious mononucleosis-like PTLD - ICD-O 9971/1

Polymorphic PTLD - ICD-O 9971/3
Monomorphic PTLD (B- and T/NK-cell type)
Classical Hodgkin lymphoma-type PTLD