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WHO classification of tumors of the nervous system

Tumors of neuroepithelial tissue

Astrocytic tumors

Pilocytic astrocytoma - ICD-O 9421/1

Pilomyxoid astrocytoma - ICD-O 9425/3

Subependymal giant cell astrocytoma - ICD-O 9384/1
Pleomorphic xanthoastrocytoma - ICD-O 9424/3
Diffuse astrocytoma - ICD-O 9400/3

Fibrillary astrocytoma - ICD-O 9420/3
Gemistocytic astrocytoma - ICD-O 9411/3
Protoplasmic astrocytoma - ICD-O 9410/3

Anaplastic astrocytoma - ICD-O 9401/3
Giloblastoma - ICD-O 9440/3

Giant cell glioblastoma - ICD-O 9441/3
Gliosarcoma - ICD-O 9442/3

Gliomatosis cerebri - ICD-O 9381/3

Oligodendroglial tumors

Oligodendroglioma - ICD-O 9450/3
Anaplastic oligodendroglioma - ICD-O 9451/3

Oligoastrocytic tumors

Oligoastrocytoma - ICD-O 9382/3
Anaplastic oligoastrocytoma - ICD-O 9382/3

Ependymal tumors

Subependymoma - ICD-O 9383/1
Myxopapillary ependymoma - ICD-O 9394/1
Ependymoma - ICD-O 9391/3

Cellular - ICD-O 9391/3
Papillary - ICD-O 9393/3
Clear cell - ICD-O 9391/3
Tanycytic - ICD-O 9391/3

Anaplastic ependymoma - ICD-O 9392/3

Choroid plexus tumors

Choroid plexus papilloma - ICD-O 9390/0
Atypical choroid plexus papilloma - ICD-O 9390/1
Choroid plexus carcinoma - ICD-O 9390/3

Other neuroepithelial tumors

Astroblastoma - ICD-O 9430/3
Chordoid glioma of the third ventricle - ICD-O 9444/1
Angiocentric glioma - ICD-O 9431/1

Neuronal and mixed neuronal-glial tumors

Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) - ICD-O 9493/0
Desmoplastic infantile astrocytoma/ganglioglioma - ICD-O 9412/1
Dysembryoplastic neuroepithelial tumor - ICD-O 9413/0
Gangliocytoma - ICD-O 9492/0
Ganglioglioma - ICD-O 9505/1
Anaplastic ganglioglioma - ICD-O 9505/3
Central neurocytoma - ICD-O 9506/1
Extraventricular neurocytoma - ICD-O 9506/1
Cerebellar liponeurocytoma - ICD-O 9506/1
Papillary glioneuronal tumor - ICD-O 9509/1
Rosette-forming glioneuronal tumor of the fourth ventricle -ICD -O 9509/1
Paraganglioma - ICD-O 8680/1

Tumors of the pineal region

Pineocytoma - ICD-O 9361/1
Pineal parenchymal tumor of intermediate differentiation - ICD-O 9362/3
Pineoblastoma - ICD-O 9362/3
Papillary tumor of the pineal region - ICD-O 9395/3

Embryonal tumors

Medulloblastoma - ICD-O 9470/3

Desmoplastic/nodular medulloblastoma - ICD-O 9471/3
Medulloblastoma with extensive nodularity - ICD-O 9471/3
Anaplastic medulloblastoma - ICD-O 9474/3
Large cell medulloblastoma - ICD-O 9474/3
Myogenic differentiation (Medullomyoblastoma) - ICD-O 9472/3
Melanotic differentiation (Melanocytic medulloblastoma) - ICD-O 9470/3

CNS primitive neuroectodermal tumor - ICD-O 9473/3

CNS Neuroblastoma - ICD-O 9500/3
CNS Ganglioneuroblastoma - ICD-O 9490/3
Medulloepithelioma - ICD-O 9501/3
Ependymoblastoma - ICD-O 9392/3

Atypical teratoid / rhabdoid tumor - ICD-O 9508/3

Tumors of cranial and paraspinal nerves

Schwannoma (neurilemoma, neurinoma) - ICD-O 9560/0

Cellular - ICD-O 9560/0
Plexiform - ICD-O 9560/0
Melanotic - ICD-O 9560/0

Neurofibroma - ICD-O 9540/0

Plexiform - ICD-O 9550/0

Perineurioma

Intraneural perineurioma - ICD-O 9571/0
Benign soft tissue perineurioma - ICD-O 9571/0
Malignant perineurioma - ICD-O 9571/3

Malignant peripheral nerve sheath tumor (MPNST) - ICD-O 9540/3

Epithelioid MPNST - ICD-O 9540/3
MPNST with mesenchymal differentiation - ICD-O 9540/3
Melanotic MPNST - ICD-O 9540/3
MPNST with glandular differentiation - ICD-O 9540/3

Tumors of the meninges

Tumors of meningothelial cells

Meningioma - ICD-O 9530/0

Meningothelial - ICD-O 9531/0
Fibrous (fibroblastic) - ICD-O 9532/0
Transitional (mixed) - ICD-O 9537/0
Psammomatous - ICD-O 9533/0
Angiomatous - ICD-O 9534/0
Microcystic - ICD-O 9530/0
Secretory - ICD-O 9530/0
Lymphoplasmacyte-rich - ICD-O 9530/0
Metaplastic - ICD-O 9530/0
Chordoid - ICD-O 9538/1
Clear cell - ICD-O 9538/1
Atypical - ICD-O 9539/1
Papillary - ICD-O 9538/3
Rhabdoid - ICD-O 9538/3
Anaplastic (malignant) - ICD-O 9530/3

Mesenchymal tumors

Lipoma - ICD-O 8850/0
Angiolipoma - ICD-O 8861/0
Hibernoma - ICD-O 8880/0
Liposarcoma - ICD-O 8850/3
Solitary fibrous tumor - ICD-O 8815/0
Fibrosarcoma - ICD-O 8810/3
Malignant fibrous histiocytoma - ICD-O 8830/3
Leiomyoma - ICD-O 8890/0
Leiomyosarcoma - ICD-O 8890/3
Rhabdomyoma - ICD-O 8900/0
Rhabdomyosarcoma - ICD-O 8900/3
Chondroma - ICD-O 9220/0
Chondrosarcoma - ICD-O 9220/3
Osteoma - ICD-O 9180/0
Osteosarcoma - ICD-O 9180/3
Osteochondroma - ICD-O 9210/0
Hemangioma - ICD-O 9120/0
Epithelioid hemangioendothelioma - ICD-O 9133/1
Hemangiopericytoma - ICD-O 9150/1
Anaplastic hemangiopericytoma - ICD-O 9150/3
Angiosarcoma - ICD-O 9120/3
Kaposi sarcoma - ICD-O 9140/3
Ewing sarcoma - PNET - ICD-O 9364/3

Primary melanocytic lesions

Diffuse melanocytosis - ICD-O 8728/0
Melanocytoma - ICD-O 8728/1
Malignant melanoma - ICD-O 8720/3
Meningeal melanomatosis - ICD-O 8728/3

Other neoplasms related to the meninges

Hemangioblastoma - ICD-O 9161/1

Lymphomas and hematopoietic neoplasms

Malignant lymphomas - ICD-O 9590/3
Plasmacytoma - ICD-O 9731/3
Granulocytic sarcoma - ICD-O 9930/3

Germ cell tumors

Germinoma - ICD-O 9064/3
Embryonal carcinoma - ICD-O 9070/3
Yolk sac tumor - ICD-O 9071/3
Choriocarcinoma - ICD-O 9100/3
Teratoma - ICD-O 9080/1

Mature - ICD-O 9080/0
Immature - ICD-O 9080/3
Teratoma with malignant transformation - ICD-O 9084/3

Mixed germ cell tumor - ICD-O 9085/3

Tumors of the sellar region

Craniopharyngioma - ICD-O 9350/1

Adamantinomatous - ICD-O 9351/1
Papillary - ICD-O 9352/1

Granular cell tumor - ICD-O 9582/0
Pituicytoma - ICD-O 9432/1
Spindle cell oncocytoma of the adenohypophysis - ICD-O 8291/0

Metastatic tumors