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WHO classification of soft tissue tumors

Adipocytic tumors

Benign

Lipoma - ICD-O 8850/0
Lipomatosis - ICD-O 8850/0
Lipomatosis of nerve - ICD-O 8850/0
Lipoblastoma / Lipoblastomatosis - ICD-O 8881/0
Angiolipoma - ICD-O 8861/0
Myolipoma - ICD-O 8890/0
Chondroid lipoma - ICD-O 8862/0
Extrarenal angiomyolipoma - ICD-O 8860/0
Extra-adrenal myelolipoma - ICD-O 8870/0
Spindle cell lipoma / - ICD-O 8857/0
Pleomorphic lipoma - ICD-O 8854/0
Hibernoma - ICD-O 8880/0

Intermediate (locally aggressive)

Atypical lipomatous tumor / Well differentiated liposarcoma - ICD-O 8851/3

Malignant

Dedifferentiated liposarcoma - ICD-O 8858/3
Myxoid liposarcoma - ICD-O 8852/3
Round cell liposarcoma - ICD-O 8853/3
Pleomorphic liposarcoma - ICD-O 8854/3
Mixed-type liposarcoma - ICD-O 8855/3
Liposarcoma, not otherwise specified - ICD-O 8850/3

Fibroblastic / Myofibroblastic tumors

Benign

Nodular fasciitis
Proliferative fasciitis
Proliferative myositis
Myositis ossificans
Fibro-osseous pseudotumor of digits
Ischemic fasciitis
Elastofibroma - ICD-O 8820/0
Fibrous hamartoma of infancy
Myofibroma / Myofibromatosis - ICD-O 8824/0
Fibromatosis colli
Juvenile hyaline fibromatosis
Inclusion body fibromatosis
Fibroma of tendon sheath - ICD-O 8810/0
Desmoplastic fibroblastoma - ICD-O 8810/0
Mammary-type myofibroblastoma - ICD-O 8825/0
Calcifying aponeurotic fibroma - ICD-O 8810/0
Angiomyofibroblastoma - ICD-O 8826/0
Cellular angiofibroma - ICD-O 9160/0
Nuchal-type fibroma - ICD-O 8810/0
Gardner fibroma - ICD-O 8810/0
Calcifying fibrous tumor - ICD-O 8810/0
Giant cell angiofibroma - ICD-O 9160/0

Intermediate (locally aggressive)

Superficial fibromatoses (palmar / plantar) - ICD-O 8821/1
Desmoid-type fibromatoses - ICD-O 8821/1
Lipofibromatosis

Intermediate (rarely metastasizing)

Solitary fibrous tumor - ICD-O 8815/1
and hemangiopericytoma - ICD-O 9150/1
(incl. lipomatous hemangiopericytoma)
Inflammatory myofibroblastic tumor - ICD-O 8825/1
Low grade myofibroblastic sarcoma - ICD-O 8825/3
Myxoinflammatory fibroblastic sarcoma - ICD-O 8811/3
Infantile fibrosarcoma - ICD-O 8814/3

Malignant

Adult fibrosarcoma - ICD-O 8810/3
Myxofibrosarcoma - ICD-O 8811/3
Low grade fibromyxoid sarcoma - ICD-O 8811/3
hyalinizing spindle cell tumor
Sclerosing epithelioid fibrosarcoma - ICD-O 8810/3

So-called fibrohistiocytic tumors

Benign

Giant cell tumor of tendon sheath - ICD-O 9252/0
Diffuse-type giant cell tumor - ICD-O 9251/0
Deep benign fibrous histiocytoma - ICD-O 8830/0

Intermediate (rarely metastasizing)

Plexiform fibrohistiocytic tumor - ICD-O 8835/1
Giant cell tumor of soft tissues - ICD-O 9251/1

Malignant

Pleomorphic 'MFH' / Undifferentiated pleomorphic sarcoma - ICD-O 8830/3
Giant cell 'MFH' / Undifferentiated pleomorphic sarcoma with giant cells - ICD-O 8830/3
Inflammatory 'MFH' / Undifferentiated pleomorphic sarcoma with prominent inflammation - ICD-O 8830/3

Smooth muscle tumors

Angioleiomyoma - ICD-O 8894/0
Deep leiomyoma - ICD-O 8890/0
Genital leiomyoma - ICD-O 8890/0
Leiomyosarcoma (excluding skin) - ICD-O 8890/3

Pericytic (Perivascular) tumors

Glomus tumor (and variants) - ICD-O 8711/0
Glomus tumors of uncertian malignant potential - ICD-O 8711/1
Malignant glomus tumor - ICD-O 8711/3
Myopericytoma - ICD-O 8713/1

Skeletal muscle tumors

Benign

Rhabdomyoma - ICD-O 8900/0

adult type - ICD-O 8904/0
fetal type - ICD-O 8903/0
genital type - ICD-O 8905/0

Malignant

Embryonal rhabdomyosarcoma - ICD-O 8910/3

(incl. spindle cell, - ICD-O 8912/3
botryoid, anaplastic) - ICD-O 8910/3

Alveolar rhabdomyosarcoma

(incl. solid) - ICD-O 8920/3

Pleomorphic rhabdomyosarcoma - ICD-O 8901/3

Vascular tumors

Benign

Hemangiomas of

subcut/deep soft tissue: - ICD-O 9120/0
capillary - ICD-O 9131/0
cavernous - ICD-O 9121/0
arteriovenous - ICD-O 9123/0
venous - ICD-O 9122/0
intramuscular - ICD-O 9132/0
synovial - ICD-O 9120/0

Epithelioid hemangioma - ICD-O 9125/0
Angiomatosis
Lymphangioma - ICD-O 9170/0

Intermediate (locally aggressive)

Kaposiform hemangioendothelioma - ICD-O 9130/1

Intermediate (rarely metastasizing)

Retiform hemangioendothelioma - ICD-O 9135/1
Papillary intralymphatic angioendothelioma - ICD-O 9135/1
Composite hemangioendothelioma - ICD-O 9130/1
Kaposi sarcoma - ICD-O 9140/3

Malignant

Epithelioid hemangioendothelioma - ICD-O 9133/3
Angiosarcoma of soft tissue - ICD-O 9120/3

Chondro-osseous tumors

Soft tissue chondroma - ICD-O 9220/0
Mesenchymal chondrosarcoma - ICD-O 9240/3
Extraskeletal osteosarcoma - ICD-O 9180/3

Tumors of uncertain differentiation

Benign

Intramuscular myxoma - ICD-O 8840/0

(incl. cellular variant)

Juxta-articular myxoma - ICD-O 8840/0
Deep ('aggressive') angiomyxoma - ICD-O 8841/0
Pleomorphic hyalinizing angiectatic tumor
Ectopic hamartomatous thymoma - ICD-O 8587/0

Intermediate (rarely metastasizing)

Angiomatoid fibrous histiocytoma - ICD-O 8836/1
Ossifying fibromyxoid tumor - ICD-O 8842/0

(incl. atypical / malignant) - ICD-O 8842/3

Mixed tumor / - ICD-O 8940/1
Myoepithelioma / - ICD-O 8982/1
Parachordoma - ICD-O 9373/1
Mixed tumor, malignant, not otherwise specified - ICD-O 8940/3

Malignant

Synovial sarcoma - ICD-O 9040/3

Synovial sarcoma, spindle cell - ICD-O 9041/3
Synovial sarcoma, biphasic - ICD-O 9043/3

Epithelioid sarcoma - ICD-O 8804/3
Alveolar soft part sarcoma - ICD-O 9581/3
Clear cell sarcoma of soft tissue - ICD-O 9044/3
Extraskeletal myxoid chondrosarcoma ("chordoid" type) - ICD-O 9231/3
PNET / Extraskeletal Ewing tumor

pPNET - ICD-O 9364/3
extraskeletal Ewing tumor - ICD-O 9260/3

Desmoplastic small round cell tumor - ICD-O 8806/3
Extra-renal rhabdoid tumor - ICD-O 8963/3
Malignant mesenchymoma - ICD-O 8990/3
Neoplasms with perivascular epithelioid cell differentiation (PEComa) clear cell myomelanocytic tumor
Intimal sarcoma - ICD-O 8800/3