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WHO histological classification of tumors of the thymus

Epithelial tumors

Thymoma - ICD-O 8580/1

Type A (spindle cell; medullary) - ICD-O 8581/1
Type AB (mixed) - ICD-O 8582/1
Type B1 (lymphocyte-rich; lymphocytic; predominantly cortical; organoid) - ICD-O 8583/1
Type B2 (cortical) - ICD-O 8584/1
Type B3 (epithelial; atypical; squamoid; well-differentiated thymic carcinoma) - ICD-O 8585/1
Micronodular thymoma - ICD-O 8580/1
Metaplastic thymoma - ICD-O 8580/1
Microscopic thymoma - ICD-O 8580/1
Sclerosing thymoma - ICD-O 8580/1
Lipofibroadenoma

Thymic carcinoma (including neuroendocrine epithelial tumors of the thymus) - ICD-O 8586/3

Squamous cell carcinoma - ICD-O 8070/3
Basaloid carcinoma - ICD-O 8123/3
Mucoepidermoid carcinoma - ICD-O 8430/3
Lymphoepithelioma-like carcinoma - ICD-O 8082/3
Sarcomatoid carcinoma (carcinosarcoma) - ICD-O 8033/3
Clear cell carcinoma - ICD-O 8310/3
Adenocarcinoma - ICD-O 8140/3
Papillary adenocarcinoma - ICD-O 8260/3
Carcinoma with t(15;19) translocation
Well-differentiated neuroendocrine carcinomas (carcinoid tumors)

Typical carcinoid - ICD-O 8240/3
Atypical carcinoid - ICD-O 8249/3

Poorly differentiatd neuroendocrine carcinomas

Large cell neuroendocrine carcinoma - ICD-O 8013/3
Small cell carcinoma, neuroendocrine type - ICD-O 8041/3

Undifferentiated carcinoma - ICD-O 8020/3
Combined thymic epithelial tumors, including neuroendocrine carcinomas

Germ cell tumors (GCT) of the mediastinum

GCTs of one histological type (pure GCTs)

Seminoma - ICD-O 9061/3
Embryonal carcinoma - ICD-O 9070/3
Yolk sac tumor - ICD-O 9071/3
Choriocarcinoma - ICD-O 9100/3
Teratoma, mature - ICD-O 9080/0
Teratoma, immature - ICD-O 9080/3

GCTs of more than one histological type (mixed GCT)

Variant: Polyembryoma - ICD-O 9072/3

GCTs with somatic-type malignancy
GCTs with associated hematologic malignancy

Mediastinal lymphomas and hematopoietic neoplasms

B-cell lymphoma

Primary mediastinal large B-cell lymphoma - ICD-O 9679/3
Thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) - ICD-O 9699/3

T-cell lymphoma

Precursor T-lymphoblastic lymphoma - ICD-O 9729/3
Precursor T-lymphoblastic leukemia - ICD-O 9837/3
[Precursor T-cell acute lymphoblastic leukemia (ALL)/Precursor T-cell lymphoblastic lymphoma (LBL)]
Anaplastic large cell lymphoma and other rare mature T- and NK-cell lymphomas of the mediastinum - ICD-O 9714/3

Hodgkin lymphoma of the mediastinum - ICD-O 9650/3
Hodgkin lymphoma, nodular sclerosis - ICD-O 9650/3
Grey zone between Hodgkin lymphoma and Non-Hodgkin lymphoma - ICD-O 9596/3
Histiocytic and dendritic cell tumors

Langerhans cell histiocytosis - ICD-O 9751/1
Langerhans cell sarcoma - ICD-O 9756/3
Histiocytic sarcoma - ICD-O 9755/3
Malignant histiocytosis - ICD-O 9750/3
Follicular dendritic cell tumor - ICD-O 9758/1
Follicular dendritic cell sarcoma - ICD-O 9758/3
Interdigitating dendritic cell tumor - ICD-O 9757/1
Interdigitating dendritic cell sarcoma - ICD-O 9757/3

Myeloid sarcoma and extramedullary acute myeloid leukemia - ICD-O 9930/3

Mesenchymal tumors of the thymus and mediastinum

Thymolipoma - ICD-O 8850/0
Lipoma of the mediastinum - ICD-O 8850/0
Liposarcoma of the mediastinum - ICD-O 8850/3
Solitary fibrous tumor - ICD-O 8815/0
Synovial sarcoma - ICD-O 9040/3
Vascular neoplasms
Rhabdomyosarcoma - ICD-O 8900/3
Leiomyomatous tumors
Tumors of peripheral nerves

Rare tumors of the mediastinum

Ectopic tumors of the thymus

Ectopic thyroid tumors
Ectopic parathyroid tumors

Metastasis to thymus and anterior mediastinum